| Literature DB >> 29438691 |
M Laura Feltri1, Yannick Poitelon2.
Abstract
Current therapies for malignant peripheral nerve sheath tumors (MPNSTs) are ineffective. The study by Wu et al. in this issue of Cancer Cell provides evidence that the HIPPO pathway is overactive in human MPNSTs and that combined modulation of LATS1/2-YAP/TAZ and PDGFR signaling in Schwann cells reduces MPNST growth.Entities:
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Year: 2018 PMID： 29438691 DOI： 10.1016/j.ccell.2018.01.016
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743