Literature DB >> 29437633

High Genetic Plasticity in Multidrug-Resistant Sequence Type 3-IncHI2 Plasmids Revealed by Sequence Comparison and Phylogenetic Analysis.

Liang-Xing Fang1,2, Xing-Ping Li1,2, Guo-Hui Deng1,2, Shu-Min Li1,2, Run-Shi Yang1,2, Zuo-Wei Wu3, Xiao-Ping Liao1,2, Jian Sun4,2, Ya-Hong Liu4,2.   

Abstract

We report a novel fusion plasmid, pP2-3T, cointegrating sequence type 3 (ST3)-IncHI2 with an IncFII plasmid backbone mediating multidrug resistance (MDR) and virulence. Phylogenetic analysis and comparative genomics revealed that pP2-3T and other MDR ST3-IncHI2 plasmids clustered together, representing a unique IncHI2 lineage that exhibited high conservation in backbones of plasmids but possessed highly genetic plasticity in various regions by acquiring numerous antibiotic resistance genes and fusing with other plasmids. Surveillance studies should be performed to monitor multiresistance IncHI2 plasmids among Enterobacteriaceae.
Copyright © 2018 American Society for Microbiology.

Keywords:  IncHI2 plasmids; cointegrated plasmids; comparative genomics; evolution; multidrug resistance

Mesh：

Year:  2018        PMID： 29437633      PMCID： PMC5913921          DOI： 10.1128/AAC.02068-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

Review 1.  Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens.

Authors:  Hatch W Stokes; Michael R Gillings
Journal:  FEMS Microbiol Rev       Date:  2011-05-20       Impact factor: 16.408

2.  Plasmid double locus sequence typing for IncHI2 plasmids, a subtyping scheme for the characterization of IncHI2 plasmids carrying extended-spectrum beta-lactamase and quinolone resistance genes.

Authors:  Aurora García-Fernández; Alessandra Carattoli
Journal:  J Antimicrob Chemother       Date:  2010-03-31       Impact factor: 5.790

Review 3.  Resistance plasmid families in Enterobacteriaceae.

Authors:  Alessandra Carattoli
Journal:  Antimicrob Agents Chemother       Date:  2009-03-23       Impact factor: 5.191

4.  Targeted conservative formation of cointegrates between two DNA molecules containing IS26 occurs via strand exchange at either IS end.

Authors:  Christopher J Harmer; Ruth M Hall
Journal:  Mol Microbiol       Date:  2017-09-04       Impact factor: 3.501

5.  IS26-mediated formation of a virulence and resistance plasmid in Salmonella Enteritidis.

Authors:  Marcus Ho-Yin Wong; Edward Wai-Chi Chan; Sheng Chen
Journal:  J Antimicrob Chemother       Date:  2017-10-01       Impact factor: 5.790

Review 6.  Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance.

Authors:  Neil Woodford; Jane F Turton; David M Livermore
Journal:  FEMS Microbiol Rev       Date:  2011-03-01       Impact factor: 16.408

7.  IncHI2 Plasmids Are the Key Vectors Responsible for oqxAB Transmission among Salmonella Species.

Authors:  Marcus Ho-Yin Wong; Edward Wai-Chi Chan; Liqi Xie; Ruichao Li; Sheng Chen
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

8.  Pebble and rock band: heuristic resolution of repeats and scaffolding in the velvet short-read de novo assembler.

Authors:  Daniel R Zerbino; Gayle K McEwen; Elliott H Margulies; Ewan Birney
Journal:  PLoS One       Date:  2009-12-22       Impact factor: 3.240

9.  Comparative genome analysis of IncHI2 VIM-1 carbapenemase-encoding plasmids of Escherichia coli and Salmonella enterica isolated from a livestock farm in Germany.

Authors:  Linda Falgenhauer; Hiren Ghosh; Beatriz Guerra; Yancheng Yao; Moritz Fritzenwanker; Jennie Fischer; Reiner Helmuth; Can Imirzalioglu; Trinad Chakraborty
Journal:  Vet Microbiol       Date:  2015-09-09       Impact factor: 3.293

10.  Easyfig: a genome comparison visualizer.

Authors:  Mitchell J Sullivan; Nicola K Petty; Scott A Beatson
Journal:  Bioinformatics       Date:  2011-01-28       Impact factor: 6.937
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  7 in total

1.  Diverse and Flexible Transmission of fosA3 Associated with Heterogeneous Multidrug Resistance Regions in Salmonella enterica Serovar Typhimurium and Indiana Isolates.

Authors:  Liang-Xing Fang; Qi Jiang; Guo-Hui Deng; Bing He; Ruan-Yang Sun; Jin-Fei Zhang; Dao-Ji Cen; Yuan-Yuan Miao; Dong Wang; Wen-Ying Guo; Jian Sun; Ya-Hong Liu; Xiao-Ping Liao
Journal:  Antimicrob Agents Chemother       Date:  2020-01-27       Impact factor: 5.191

2.  Urban Wildlife Crisis: Australian Silver Gull Is a Bystander Host to Widespread Clinical Antibiotic Resistance.

Authors:  Ethan R Wyrsch; Kristina Nesporova; Hassan Tarabai; Ivana Jamborova; Ibrahim Bitar; Ivan Literak; Monika Dolejska; Steven P Djordjevic
Journal:  mSystems       Date:  2022-04-26       Impact factor: 7.324

3.  Formation, Transmission, and Dynamic Evolution of a Multidrug-Resistant Chromosomally Integrated Plasmid in Salmonella Spp.

Authors:  Man-Xia Chang; Jing Zhang; Jin-Fei Zhang; Xiao-Min Ding; Yang Lu; Jie Zhang; Ruichao Li; Hong-Xia Jiang
Journal:  Front Microbiol       Date:  2022-04-06       Impact factor: 5.640

4.  The bla NDM-1-Carrying IncA/C2 Plasmid Underlies Structural Alterations and Cointegrate Formation In Vivo.

Authors:  Sead Hadziabdic; Jennie Fischer; Maria Borowiak; Burkhard Malorny; Katharina Juraschek; Annemarie Kaesbohrer; Beatriz Guerra; Carlus Deneke; Bruno Gonzalez-Zorn; Istvan Szabo
Journal:  Antimicrob Agents Chemother       Date:  2019-07-25       Impact factor: 5.191

5.  The co-transfer of plasmid-borne colistin-resistant genes mcr-1 and mcr-3.5, the carbapenemase gene blaNDM-5 and the 16S methylase gene rmtB from Escherichia coli.

Authors:  Haiyan Long; Yu Feng; Ke Ma; Lu Liu; Alan McNally; Zhiyong Zong
Journal:  Sci Rep       Date:  2019-01-24       Impact factor: 4.379

6.  Diverse Commensal Escherichia coli Clones and Plasmids Disseminate Antimicrobial Resistance Genes in Domestic Animals and Children in a Semirural Community in Ecuador.

Authors:  Liseth Salinas; Paúl Cárdenas; Timothy J Johnson; Karla Vasco; Jay Graham; Gabriel Trueba
Journal:  mSphere       Date:  2019-05-22       Impact factor: 4.389

7.  Characterization of the global distribution and diversified plasmid reservoirs of the colistin resistance gene mcr-9.

Authors:  Ying Li; Xiaoyi Dai; Jing Zeng; Yan Gao; Zhikun Zhang; Luhua Zhang
Journal:  Sci Rep       Date:  2020-05-15       Impact factor: 4.379
  7 in total

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