Yudan Zhu 1 , Shuzhang Zhang 2 , Yijun Feng 2 , Qian Xiao 1 , Jiwei Cheng 1 , Jie Tao 1 Show Affiliations »
Abstract
BACKGROUND & OBJECTIVE: The large conductance calcium-activated potassium (BK) channel, extensively distributed in the central nervous system (CNS), is considered as a vital player in the pathogenesis of epilepsy, with evidence implicating derangement of K+ as well as regulating action potential shape and duration. However, unlike other channels implicated in epilepsy whose function in neurons could clearly be labeled "excitatory" or "inhibitory", the unique physiological behavior of the BK channel allows it to both augment and decrease the excitability of neurons. Thus, the role of BK in epilepsy is controversial so far, and a growing area of intense investigation. CONCLUSION: Here, this review aims to highlight recent discoveries on the dichotomous role of BK channels in epilepsy, focusing on relevant BK-dependent pro- as well as antiepileptic pathways, and discuss the potential of BK specific modulators for the treatment of epilepsy. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND & ; OBJECTIVE: The large conductance calcium-activated potassium (BK ) channel, extensively distributed in the central nervous system (CNS), is considered as a vital player in the pathogenesis of epilepsy , with evidence implicating derangement of K+ as well as regulating action potential shape and duration. However, unlike other channels implicated in epilepsy whose function in neurons could clearly be labeled "excitatory" or "inhibitory", the unique physiological behavior of the BK channel allows it to both augment and decrease the excitability of neurons. Thus, the role of BK in epilepsy is controversial so far, and a growing area of intense investigation. CONCLUSION: Here, this review aims to highlight recent discoveries on the dichotomous role of BK channels in epilepsy , focusing on relevant BK -dependent pro- as well as antiepileptic pathways, and discuss the potential of BK specific modulators for the treatment of epilepsy . Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Chemical
Disease
Keywords:
Action potential; BK channel; auxiliary subunit; epilepsy; large conductance; specific modulator.
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Year: 2018
PMID： 29437015 DOI： 10.2174/1871527317666180213142403
Source DB: PubMed Journal: CNS Neurol Disord Drug Targets ISSN： 1871-5273 Impact factor: 4.388