Literature DB >> 2943700

Hemoglobin J Iran alpha 2 beta 2 77 (EF1) his----Asp in a Russian-Armenian family.

J Delanoe-Garin, M D Rhoda, C T Craescu, J Bardakjian, Y Blouquit, C Lacombe, N Arous, C Poyart, D Ganeval, R Girot.   

Abstract

A third case of Hb J Iran is reported. The propositus is of Russian-Armenian origin and was investigated for hematuria. The electrophoretic behavior and the characterization of primary structure are described. Hb J Iran is stable and has normal functional properties. High resolution Nuclear Magnetic Resonance spectra suggest the presence of structural perturbations in the heme pocket of the variant. Solubility studies of Hb S/Hb J Iran mixture indicated that His beta 77 belongs to a contact region of deoxy Hb S polymers.

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Year:  1986        PMID: 2943700     DOI: 10.3109/03630268608996868

Source DB:  PubMed          Journal:  Hemoglobin        ISSN: 0363-0269            Impact factor:   0.849


  1 in total

1.  Combined α-thalassemia and Hemoglobin J-Iran (β77 His → Asp). A Family Study in southern Iran.

Authors:  S J Dehghani; A Amiri Dashtarzhen; Sh Nasirabadi; J Dehbozorgian; A R Afrasiabi; N Morshedi; J Imanifard; Sh Mehrpoor; J Gerdabi; M Karimi
Journal:  Iran Red Crescent Med J       Date:  2011-08-01       Impact factor: 0.611

  1 in total

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