Literature DB >> 29435884

Isolation of cytochrome P450 3A (CYP3A) inhibitors from Hyuganatsu, Citrus tamurana Hort.

Shinzo Hosoi1, Eri Shimizu2, Noriyuki Usami2, Ikuo Yamamoto2, Kazuhiko Arimori3, Manabu Okumura3, Muneaki Hidaka3, Mitsuko Yamada4, Akiyo Sakushima2.   

Abstract

The present study was conducted to identify cytochrome P450 3A (CYP3A) inhibitory components of Hyuganatsu, Citrus tamurana Hort., by investigating the effects on midazolam 1'-hydroxylase activity of human liver microsomes. As a consequence, limonin and nomilin were identified as CYP3A inhibitors from the endocarp of Hyuganatsu.

Entities:  

Keywords:  CYP 3A; Citrus tamurana; Enzyme inhibitor; Hyuganatsu; Limonoid

Year:  2006        PMID： 29435884     DOI： 10.1007/s11418-006-0031-9

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  8 in total

1.  Grapefruit component interacting with rat and human P450 CYP3A: possible involvement of non-flavonoid components in drug interaction.

Authors:  K Fukuda; T Ohta; Y Yamazoe
Journal:  Biol Pharm Bull       Date:  1997-05       Impact factor: 2.233

2.  Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract.

Authors:  Hiroshi Iwata; Yasuhiro Tezuka; Shigetoshi Kadota; Akira Hiratsuka; Tadashi Watabe
Journal:  Drug Metab Pharmacokinet       Date:  2005-02       Impact factor: 3.614

Review 3.  Grapefruit juice and drugs. How significant is the interaction?

Authors:  D G Bailey; J M Arnold; J D Spence
Journal:  Clin Pharmacokinet       Date:  1994-02       Impact factor: 6.447

4.  Effect of grapefruit juice on blood cyclosporin concentration.

Authors:  G C Yee; D L Stanley; L J Pessa; T Dalla Costa; S E Beltz; J Ruiz; D T Lowenthal
Journal:  Lancet       Date:  1995-04-15       Impact factor: 79.321

5.  Disposition of intravenous and oral cyclosporine after administration with grapefruit juice.

Authors:  M P Ducharme; L H Warbasse; D J Edwards
Journal:  Clin Pharmacol Ther       Date:  1995-05       Impact factor: 6.875

6.  Potent inhibition by star fruit of human cytochrome P450 3A (CYP3A) activity.

Authors:  Muneaki Hidaka; Ken-ichi Fujita; Tetsuya Ogikubo; Keishi Yamasaki; Tomomi Iwakiri; Manabu Okumura; Hirofumi Kodama; Kazuhiko Arimori
Journal:  Drug Metab Dispos       Date:  2004-06       Impact factor: 3.922

7.  Inhibitory effects of citrus fruits on cytochrome P450 3A (CYP3A) activity in humans.

Authors:  Ken-Ichi Fujita; Muneaki Hidaka; Norito Takamura; Keishi Yamasaki; Tomomi Iwakiri; Manabu Okumura; Hirofumi Kodama; Masatoshi Yamaguchi; Tsuyomu Ikenoue; Kazuhiko Arimori
Journal:  Biol Pharm Bull       Date:  2003-09       Impact factor: 2.233

8.  Interaction between grapefruit juice and midazolam in humans.

Authors:  H H Kupferschmidt; H R Ha; W H Ziegler; P J Meier; S Krähenbühl
Journal:  Clin Pharmacol Ther       Date:  1995-07       Impact factor: 6.875
  8 in total
  1 in total

Review 1.  Limonin: A Review of Its Pharmacology, Toxicity, and Pharmacokinetics.

Authors:  Shunming Fan; Chunling Zhang; Ting Luo; Jiaqi Wang; Yu Tang; Zhimin Chen; Lingying Yu
Journal:  Molecules       Date:  2019-10-12       Impact factor: 4.411
  1 in total

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