| Literature DB >> 29433927 |
Sven Ruf1, Mahanandeesha Siddappa Hallur2, Nisha K Anchan2, Indu N Swamy2, Karthikai Raj Murugesan2, Sayantani Sarkar2, Lokesh Kananti Narasimhulu2, V P Rama Kishore Putta2, Shama Shaik3, Devaraj Venkatapura Chandrasekar4, Vishal Subhash Mane3, Sanjay Venkatachalapathi Kadnur3, Juluri Suresh3, Ravi Kanth Bhamidipati4, Manvi Singh5, Raghunadha Reddy Burri5, Rajendra Kristam5, Herman Schreuder6, Joerg Czech6, Christine Rudolph6, Alexander Marker7, Thomas Langer8, Ramesh Mullangi4, Takeshi Yura2, Ramachandraiah Gosu4, Aimo Kannt9, Saravanakumar Dhakshinamoorthy3, Sridharan Rajagopal10.
Abstract
Nicotinamide N-methyltransferase (NNMT) has been linked to obesity and diabetes. We have identified a novel nicotinamide (NA) analog, compound 12 that inhibited NNMT enzymatic activity and reduced the formation of 1-methyl-nicotinamide (MNA), the primary metabolite of NA by ∼80% at 2 h when dosed in mice orally at 50 mg/kg.Entities:
Keywords: Diabetes; Methyl-nicotinamide (MNA); Ncotinamide; Nicotinamide N-methyltransferase (NNMT); Obesity
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Year: 2018 PMID： 29433927 DOI： 10.1016/j.bmcl.2018.01.058
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823