Literature DB >> 2943335

Antithrombotic effect of a monoclonal antibody to the platelet glycoprotein IIb/IIIa receptor in an experimental animal model.

B S Coller, J D Folts, L E Scudder, S R Smith.   

Abstract

A murine monoclonal antibody directed at the platelet glycoprotein IIb/IIIa complex, which blocks platelet aggregation ex vivo, was tested for its antithrombotic effects in an established animal model of acute platelet thrombus formation in partially stenosed arteries. Infusion of 0.7 to 0.8 mg/kg of the F(ab')2 fragment of the antibody completely blocked new thrombus formation despite multiple provocations, making it the most potent antithrombotic agent tested in this model.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 2943335

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  28 in total

Review 1.  Platelet glycoprotein IIb/IIIa receptor antagonists: current concepts and future directions.

Authors:  J J Ferguson; M Zaqqa
Journal:  Drugs       Date:  1999-12       Impact factor: 9.546

2.  Biography of Barry S. Coller.

Authors:  Christen Brownlee
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-30       Impact factor: 11.205

3.  Platelet Glycoprotein IIb/IIIa Integrin Blockade in Coronary Artery Disease: Current State of the Art.

Authors: 
Journal:  J Thromb Thrombolysis       Date:  1997       Impact factor: 2.300

4.  Inhibition of platelet aggregation with a glycoprotein IIb-IIIa antagonist does not prevent thrombin generation in patients undergoing thrombolysis for acute myocardial infarction.

Authors:  N S Kleiman; R P Tracy; J D Talley; K Sigmon; D Joseph; E J Topol; R M Califf; M Kitt; E M Ohman
Journal:  J Thromb Thrombolysis       Date:  2000-01       Impact factor: 2.300

Review 5.  Pharmacological approaches to the prevention of restenosis following angioplasty. The search for the Holy Grail? (Part II).

Authors:  J P Herrman; W R Hermans; J Vos; P W Serruys
Journal:  Drugs       Date:  1993-08       Impact factor: 9.546

Review 6.  Platelet GPIIb/IIIa antagonists: the first anti-integrin receptor therapeutics.

Authors:  B S Coller
Journal:  J Clin Invest       Date:  1997-04-01       Impact factor: 14.808

7.  Agkistrodon piscivorus piscivorus platelet aggregation inhibitor: a potent inhibitor of platelet activation.

Authors:  B H Chao; J A Jakubowski; B Savage; E P Chow; U M Marzec; L A Harker; J M Maraganore
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

8.  Effects of trimetazidine on in vivo coronary arterial platelet thrombosis.

Authors:  P R Belcher; A J Drake-Holland; J W Hynd; M I Noble
Journal:  Cardiovasc Drugs Ther       Date:  1993-02       Impact factor: 3.727

9.  The platelet: life on the razor's edge between hemorrhage and thrombosis.

Authors:  Barry S Coller
Journal:  Transfusion       Date:  2014-08-05       Impact factor: 3.157

10.  Actual Role of Platelet Glycoprotein IIb/IIIa Receptor Inhibitors as Adjunctive Pharmacological Therapy to Primary Angioplasty in Acute Myocardial Infarction: In the Light of Recent Randomized Trials and Observational Studies with Bivalirudin.

Authors:  Osmar Antonio Centurión
Journal:  Open Cardiovasc Med J       Date:  2010-06-17
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.