Joanna Cwikiel1, Ingebjørg Seljeflot2, Eivind Berge3, Ida Unhammer Njerve4, Hilde Ulsaker5, Harald Arnesen6, Arnljot Flaa7. 1. Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevaal, Norway; Faculty of Medicine, University of Oslo, Norway; Section of Cardiovascular and Renal Research, Oslo University Hospital Ulleval, Norway. Electronic address: joacwi@ous-hf.no. 2. Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevaal, Norway; Department of Cardiology, Oslo University Hospital Ullevaal, Norway; Faculty of Medicine, University of Oslo, Norway. Electronic address: uxinlj@ous-hf.no. 3. Department of Cardiology, Oslo University Hospital Ullevaal, Norway. Electronic address: eivind.berge@medisin.uio.no. 4. Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevaal, Norway. Electronic address: idaunh@ous-hf.no. 5. Modum Bad, Vikersund, Norway. Electronic address: hildeulsaker@gmail.com. 6. Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevaal, Norway; Faculty of Medicine, University of Oslo, Norway. Electronic address: uxhaar@ous-hf.no. 7. Department of Cardiology, Oslo University Hospital Ullevaal, Norway; Section of Cardiovascular and Renal Research, Oslo University Hospital Ulleval, Norway. Electronic address: arnljot.flaa@gmail.com.
Abstract
BACKGROUND: Coronary artery disease (CAD) is considered a low-grade inflammatory disease. We aimed to identify effects of short-term strenuous exercise on mediators of systemic inflammation, endothelial and platelet activation in patients with angiographically verified CAD. We hypothesized that a more pronounced inflammatory response would be present in patients with CAD than in those without CAD. METHODS: In subjects with symptoms indicative of stable CAD, an exercise stress test on a bicycle ergometer was performed. Venous blood samples, taken at rest and within 5 min after end of exercise, were analyzed for the following markers by ELISAs: TNF-α, IL-6, MCP-1, ICAM-1, VCAM-1, E-selectin, P-selectin, CD40L and RANTES. All participants underwent conventional coronary angiography. CAD was defined as having any degree of atherosclerosis. RESULTS: A total of 110 patients were included, of whom 74 were found to have CAD. Mean exercise duration was 10:06 ± 3:56 min with no significant difference between the two groups. All measured markers changed significantly during exercise (p ≤ 0.012). A significantly less pronounced increase in CD40L in the CAD group than in the no CAD group was observed (p = 0.050), however, after adjustment for hematocrit this difference was no longer significant. CONCLUSION: An instant inflammatory response was observed during short-term strenuous exercise in patients with symptoms of CAD. However, the exercise mediated response was not more pronounced in patients with CAD.
BACKGROUND:Coronary artery disease (CAD) is considered a low-grade inflammatory disease. We aimed to identify effects of short-term strenuous exercise on mediators of systemic inflammation, endothelial and platelet activation in patients with angiographically verified CAD. We hypothesized that a more pronounced inflammatory response would be present in patients with CAD than in those without CAD. METHODS: In subjects with symptoms indicative of stable CAD, an exercise stress test on a bicycle ergometer was performed. Venous blood samples, taken at rest and within 5 min after end of exercise, were analyzed for the following markers by ELISAs: TNF-α, IL-6, MCP-1, ICAM-1, VCAM-1, E-selectin, P-selectin, CD40L and RANTES. All participants underwent conventional coronary angiography. CAD was defined as having any degree of atherosclerosis. RESULTS: A total of 110 patients were included, of whom 74 were found to have CAD. Mean exercise duration was 10:06 ± 3:56 min with no significant difference between the two groups. All measured markers changed significantly during exercise (p ≤ 0.012). A significantly less pronounced increase in CD40L in the CAD group than in the no CAD group was observed (p = 0.050), however, after adjustment for hematocrit this difference was no longer significant. CONCLUSION: An instant inflammatory response was observed during short-term strenuous exercise in patients with symptoms of CAD. However, the exercise mediated response was not more pronounced in patients with CAD.
Authors: Sílvia Thamilis Barbosa Pessoa Ferreira; Maria do Socorro Brasileiro-Santos; Juliana Baptista Teixeira; Michelle Christiane da Silva Rabello; Virgínia Maria Barros de Lorena; Breno Quintella Farah; Thayse Neves Santos Silva; Anna Myrna Jaguaribe de Lima Journal: Sleep Breath Date: 2021-04-05 Impact factor: 2.816
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