| Literature DB >> 29432762 |
Silvério Ferreira Silva Filho1, Andreia Cardoso Pereira1, Jorge M G Sarraguça1, Mafalda C Sarraguça2, João Lopes3, Pedro de Freitas Façanha Filho1, Adenilson Oliveira Dos Santos1, Paulo Roberto da Silva Ribeiro4.
Abstract
A cocrystal of glibenclamide, an antidiabetic drug classified as type II compound according to the Biopharmaceutics Classification System, has been synthesized using tromethamine as coformer in 1:1 molar ratio, by slow solvent evaporation cocrystalization. The cocrystal obtained was characterized by X-ray powder diffraction, differential scanning calorimetry, Raman, mid infrared, and near-infrared spectroscopy. The results consistently show the formation of a cocrystal between active pharmaceutical ingredients and conformer with the synthons corresponding to hydrogen bonding between hydrogen in amines of tromethamine and carbonyl and sulfonyl groups in glibenclamide.Entities:
Keywords: FTIR; Raman spectroscopy; X-ray powder diffractometry; calorimetry (DSC); co-crystals; near-infrared spectroscopy
Mesh：
Substances：
Year: 2018 PMID： 29432762 DOI： 10.1016/j.xphs.2018.01.029
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534