Amy L Slogrove1, Annette H Sohn2. 1. Department of Paediatrics & Child Health and Ukwanda Centre for Rural Health, Faculty of Medicine & Health Sciences, Stellenbosch University, Cape Town, South Africa. 2. TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
Abstract
PURPOSE OF REVIEW: The aim of this study was to summarize recent evidence on the global epidemiology of adolescents (age 10-19 years) living with HIV (ALHIV), the burden of HIV on the health of adolescents and HIV-associated mortality. RECENT FINDINGS: In 2016, there were an estimated 2.1 million (uncertainty bound 1.4-2.7 million) ALHIV; 770 000 younger (age 10-14 years) and 1.03 million older (age 15-19 years) ALHIV, 84% living in sub-Saharan Africa. The population of ALHIV is increasing, as more peri/postnatally infected ALHIV survive into older ages; an estimated 35% of older female ALHIV were peri/postnatally infected, compared with 57% of older male ALHIV. Although the numbers of younger ALHIV deaths are declining, deaths among older ALHIV have remained static since peaking in 2012. In 2015, HIV-associated mortality was the eighth leading cause of adolescent death globally and the fourth leading cause in African low and middle-income countries. SUMMARY: Needed investments into characterizing and improving adolescent HIV-related health outcomes include strengthening systems for nationally and globally disaggregated data by age, sex and mode of infection; collecting more granular data within routine programmes to identify structural, social and mental health challenges to accessing testing and care; and prioritizing viral load monitoring and adolescent-focused differentiated models of care.
PURPOSE OF REVIEW: The aim of this study was to summarize recent evidence on the global epidemiology of adolescents (age 10-19 years) living with HIV (ALHIV), the burden of HIV on the health of adolescents and HIV-associated mortality. RECENT FINDINGS: In 2016, there were an estimated 2.1 million (uncertainty bound 1.4-2.7 million) ALHIV; 770 000 younger (age 10-14 years) and 1.03 million older (age 15-19 years) ALHIV, 84% living in sub-Saharan Africa. The population of ALHIV is increasing, as more peri/postnatally infected ALHIV survive into older ages; an estimated 35% of older female ALHIV were peri/postnatally infected, compared with 57% of older male ALHIV. Although the numbers of younger ALHIV deaths are declining, deaths among older ALHIV have remained static since peaking in 2012. In 2015, HIV-associated mortality was the eighth leading cause of adolescent death globally and the fourth leading cause in African low and middle-income countries. SUMMARY: Needed investments into characterizing and improving adolescent HIV-related health outcomes include strengthening systems for nationally and globally disaggregated data by age, sex and mode of infection; collecting more granular data within routine programmes to identify structural, social and mental health challenges to accessing testing and care; and prioritizing viral load monitoring and adolescent-focused differentiated models of care.
Authors: Anne M Neilan; Brad Karalius; Kunjal Patel; Russell B Van Dyke; Mark J Abzug; Allison L Agwu; Paige L Williams; Murli Purswani; Deborah Kacanek; James M Oleske; Sandra K Burchett; Andrew Wiznia; Miriam Chernoff; George R Seage; Andrea L Ciaranello Journal: JAMA Pediatr Date: 2017-05-01 Impact factor: 16.193
Authors: Katrina D Hermetet-Lindsay; Katharine F Correia; Paige L Williams; Renee Smith; Kathleen M Malee; Claude A Mellins; Richard M Rutstein Journal: AIDS Behav Date: 2017-09
Authors: Matthias Egger; Ben D Spycher; John Sidle; Ralf Weigel; Elvin H Geng; Matthew P Fox; Patrick MacPhail; Gilles van Cutsem; Eugène Messou; Robin Wood; Denis Nash; Margaret Pascoe; Diana Dickinson; Jean-François Etard; James A McIntyre; Martin W G Brinkhof Journal: PLoS Med Date: 2011-01-18 Impact factor: 11.069
Authors: Amir Shroufi; Wedu Ndebele; Mary Nyathi; Hilary Gunguwo; Mark Dixon; Jean F Saint-Sauveur; Fabian Taziwa; Mari C Viñoles; Rashida A Ferrand Journal: J Int AIDS Soc Date: 2015-02-23 Impact factor: 5.396
Authors: Christopher J Lin; Yao I Cheng; Patricia A Garvie; Lawrence J D'Angelo; Jichuan Wang; Maureen E Lyon Journal: J Fam Nurs Date: 2020-11 Impact factor: 3.818
Authors: Lonnie Embleton; Carmen H Logie; Kenneth Ngure; LaRon Nelson; Liza Kimbo; David Ayuku; Janet M Turan; Paula Braitstein Journal: AIDS Behav Date: 2022-07-30
Authors: Sarah Mulwa; Jane Osindo; Elvis O Wambiya; Annabelle Gourlay; Beatrice W Maina; Benedict O Orindi; Sian Floyd; Abdhalah Ziraba; Isolde Birdthistle Journal: BMC Public Health Date: 2021-06-10 Impact factor: 3.295
Authors: Anne M Neilan; Frances Lu; Kelly A Gebo; Rebeca Diaz-Reyes; Mingshu Huang; Robert A Parker; Brad Karalius; Kunjal Patel; Cindy Voss; Andrea L Ciaranello; Allison L Agwu Journal: J Acquir Immune Defic Syndr Date: 2020-04-01 Impact factor: 3.771
Authors: Áine Aventin; Stephan Rabie; Sarah Skeen; Mark Tomlinson; Moroesi Makhetha; Zenele Siqabatiso; Maria Lohan; Mike Clarke; Lynne Lohfeld; Allen Thurston; Jackie Stewart Journal: Glob Health Action Date: 2021-01-01 Impact factor: 2.640