Guopeng Liang1, Tingting Liu1, Yihua Zeng2, Yunfeng Shi1, Wei Yang1, Yunqin Yang1, Yan Kang3. 1. Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China. 2. Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China. 3. Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China. Kang_yan_123@yahoo.com Kang_yan_123@163.com.
Abstract
BACKGROUND: The objective of this work was to identify the unique characteristics of patients who experienced success in a 30-min spontaneous breathing trial (SBT) but failed at 120 min. METHODS: Patients who had received mechanical ventilation for >24 h were eligible for inclusion in this study. The SBT was performed by 7 cm H2O of pressure support with zero PEEP. After a successful 120-min SBT, weaning from mechanical ventilation was performed. Data were collected at 30 and 120 min or at the failure of the SBT. All patients who successfully completed a 30-min SBT were enrolled. RESULTS: We enrolled 352 subjects in this study. Of these, 311 subjects (88.4%) directly completed a 120-min SBT (success group), and 41 subjects (11.6%) passed the test for at least 30 min but failed before 120 min (failure group). In data collected before the SBT, presence of chronic cardiopulmonary disease, number of previous SBT attempts before 30-min SBT success, age, and PaCO2 were independently associated with 120-min SBT failure. A scale was developed that used these 4 variables. The failure rate was low in subjects with ≤2 points (3%) but significantly higher in subjects with >2 points (46%). In data collected at the 30-min SBT, PaCO2 , rapid shallow breathing index, ΔPaO2 /FIO2 , Δbreathing frequency, and ΔpH were independently associated with 120-min SBT failure. These 5 variables were then used to develop another scale to predict SBT success. Similar to the previous score, the failure rate was low in subjects with ≤2 points (1%) and significantly higher in subjects with >2 points (55%). CONCLUSIONS: This study highlights differences between subjects who completed a 120-min SBT and those who succeeded at 30 min but failed by 120 min. In subjects with a score >2 points, reflecting a greater risk of SBT failure, a 120-min SBT may be required.
BACKGROUND: The objective of this work was to identify the unique characteristics of patients who experienced success in a 30-min spontaneous breathing trial (SBT) but failed at 120 min. METHODS:Patients who had received mechanical ventilation for >24 h were eligible for inclusion in this study. The SBT was performed by 7 cm H2O of pressure support with zero PEEP. After a successful 120-min SBT, weaning from mechanical ventilation was performed. Data were collected at 30 and 120 min or at the failure of the SBT. All patients who successfully completed a 30-min SBT were enrolled. RESULTS: We enrolled 352 subjects in this study. Of these, 311 subjects (88.4%) directly completed a 120-min SBT (success group), and 41 subjects (11.6%) passed the test for at least 30 min but failed before 120 min (failure group). In data collected before the SBT, presence of chronic cardiopulmonary disease, number of previous SBT attempts before 30-min SBT success, age, and PaCO2 were independently associated with 120-min SBT failure. A scale was developed that used these 4 variables. The failure rate was low in subjects with ≤2 points (3%) but significantly higher in subjects with >2 points (46%). In data collected at the 30-min SBT, PaCO2 , rapid shallow breathing index, ΔPaO2 /FIO2 , Δbreathing frequency, and ΔpH were independently associated with 120-min SBT failure. These 5 variables were then used to develop another scale to predict SBT success. Similar to the previous score, the failure rate was low in subjects with ≤2 points (1%) and significantly higher in subjects with >2 points (55%). CONCLUSIONS: This study highlights differences between subjects who completed a 120-min SBT and those who succeeded at 30 min but failed by 120 min. In subjects with a score >2 points, reflecting a greater risk of SBT failure, a 120-min SBT may be required.
Authors: Carles Subirà; Gonzalo Hernández; Antònia Vázquez; Raquel Rodríguez-García; Alejandro González-Castro; Carolina García; Olga Rubio; Lara Ventura; Alexandra López; Maria-Carmen de la Torre; Elena Keough; Vanesa Arauzo; Cecilia Hermosa; Carmen Sánchez; Ana Tizón; Eva Tenza; César Laborda; Sara Cabañes; Victoria Lacueva; Maria Del Mar Fernández; Anna Arnau; Rafael Fernández Journal: JAMA Date: 2019-06-11 Impact factor: 56.272