Literature DB >> 29431435

A New Ratiometric Lysosomal Copper(II) Fluorescent Probe To Map a Dynamic Metallome in Live Cells.

Maria Laura Giuffrida1, Giuseppe Trusso Sfrazzetto, Cristina Satriano, Stefania Zimbone1, Gaetano A Tomaselli, Agata Copani1, Enrico Rizzarelli1.   

Abstract

We synthesized a new ratiometric fluorescent Cu2+ probe, bearing a morpholine moiety for selective binding to lysosomes and two picolylamine arms for the specific chelation of divalent copper ions. The probe capability to detect lysosomal Cu2+ was demonstrated in human differentiated neuroblastoma cells by confocal microscopy.

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Year:  2018        PMID： 29431435     DOI： 10.1021/acs.inorgchem.7b02720

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  3 in total

1.  Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism.

Authors:  Clive Yik-Sham Chung; Jessica M Posimo; Sumin Lee; Tiffany Tsang; Julianne M Davis; Donita C Brady; Christopher J Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2019-08-26       Impact factor: 11.205

2.  Activity-Based Sensing with a Metal-Directed Acyl Imidazole Strategy Reveals Cell Type-Dependent Pools of Labile Brain Copper.

Authors:  Sumin Lee; Clive Yik-Sham Chung; Pei Liu; Laura Craciun; Yuki Nishikawa; Kevin J Bruemmer; Itaru Hamachi; Kaoru Saijo; Evan W Miller; Christopher J Chang
Journal:  J Am Chem Soc       Date:  2020-08-20       Impact factor: 15.419

3.  Supramolecular Sensing of a Chemical Warfare Agents Simulant by Functionalized Carbon Nanoparticles.

Authors:  Nunzio Tuccitto; Luca Spitaleri; Giovanni Li Destri; Andrea Pappalardo; Antonino Gulino; Giuseppe Trusso Sfrazzetto
Journal:  Molecules       Date:  2020-12-04       Impact factor: 4.411
  3 in total

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