S W Youn1, J-H Lee2, D Y Yu3, Y Kim3, B S Kim4, S J Seo5, Y B Choe6, S-K Yun7, J Park8, N I Kim9, C W Choi1, J I Youn10, S-J Lee11, M-G Lee12, K J Kim13, C J Park14, Y S Ro15, H J Song16, B S Shin17, S K Ahn18, J Y Lee19, Y H Won20, M S Jang21, K H Kim22, M H Kim23, T Y Kim24, J-H Choi25. 1. Department of Dermatology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. 2. Department of Dermatology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea. 3. Medical Affairs, Janssen Korea, Seoul, Korea. 4. Department of Dermatology, Pusan National University School of Medicine, Busan, Korea. 5. Department of Dermatology, Chung-Ang University Hospital, Seoul, Korea. 6. Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea. 7. Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea. 8. Department of Dermatology, Catholic University of Daegu School of Medicine, Daegu, Korea. 9. Department of Dermatology, KyungHee University Medical center, Seoul, Korea. 10. Department of Dermatology, National Medical Center, Seoul, Korea. 11. Department of Dermatology, Kyungpook National University Hospital, Daegu, Korea. 12. Department of Dermatology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. 13. Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea. 14. Department of Dermatology, The Catholic University of Korea, Bucheon St. Mary's Hospital, Bucheon, Korea. 15. Department of Dermatology, Hanyang University Medical Center, Seoul, Korea. 16. Department of Dermatology, Korea University Guro Hospital, Seoul, Korea. 17. Department of Dermatology, Chosun University Hospital, Gwangju, Korea. 18. Department of Dermatology, Wonju Severance Christian Hospital, Wonju, Korea. 19. Department of Dermatology, Chungbuk National University College of Medicine, Cheongju, Korea. 20. Department of Dermatology, Chonnam National University Hospital, Gwangju, Korea. 21. Department of Dermatology, Kosin University College of Medicine, Busan, Korea. 22. Department of Dermatology, Dong-A University Hospital, Busan, Korea. 23. Department of Dermatology, Dankook University Hospital, Cheonan, Korea. 24. Department of Dermatology, Catholic University of Korea Seoul St. Mary's Hospital, Seoul, Korea. 25. Department of Dermatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Abstract
BACKGROUND: Psychological aspect and quality of life should be considered in treating patients with psoriasis. OBJECTIVE: We sought to ascertain which clinical characteristics including presence of exposed lesions are associated with impairment of health-related quality of life (HRQoL) in patients with psoriasis. METHODS: The EPI-PSODE study was a nationwide, multicenter, cross-sectional study conducted in Korea that included 1260 adult patients with psoriasis. In addition to clinical characteristics including presence of exposed lesions, data were collected using the Psoriatic Arthritis (PsA) Screening and Evaluation (PASE), Dermatology Life Quality Index (DLQI), MOS 36-Item Short-Form Health Survey (SF-36), Work Productivity and Activity Impairment Questionnaire Psoriasis (WPAI: PSO) and Medication Satisfaction Questionnaire (MSQ). RESULTS: Patients with a DLQI score > 5 (n = 990) were younger, had an earlier onset of psoriasis, scored higher on the Psoriasis Area and Severity Index (PASI), had higher body surface area (BSA) and had higher PASE scores than patients with DLQI ≤ 5 (n = 266). The group of patients with exposed lesions (n = 871) were younger and male predominance, earlier onset of psoriasis, longer disease duration, higher PASI/BSA score and a higher proportion with drinking and smoking history each than the group of patients without exposed lesions (n = 389). Presence of exposed lesions negatively influenced DLQI, 36-Item Short-Form Health Survey (SF-36) (mental component), presenteeism, total work productivity impairment and total activity impairment in the WPAI: PSO. In multiple regression model, PASI score was the only variable which was significantly associated with all HRQoL measures. Presence of exposed lesions was a significant factor affecting DLQI and SF-36 (mental). CONCLUSION: The presence of exposed lesions has a negative impact on quality of life, mental health and work productivity. Therefore, effective treatments are particularly needed for psoriasis patients with exposed lesions.
BACKGROUND: Psychological aspect and quality of life should be considered in treating patients with psoriasis. OBJECTIVE: We sought to ascertain which clinical characteristics including presence of exposed lesions are associated with impairment of health-related quality of life (HRQoL) in patients with psoriasis. METHODS: The EPI-PSODE study was a nationwide, multicenter, cross-sectional study conducted in Korea that included 1260 adult patients with psoriasis. In addition to clinical characteristics including presence of exposed lesions, data were collected using the Psoriatic Arthritis (PsA) Screening and Evaluation (PASE), Dermatology Life Quality Index (DLQI), MOS 36-Item Short-Form Health Survey (SF-36), Work Productivity and Activity Impairment Questionnaire Psoriasis (WPAI: PSO) and Medication Satisfaction Questionnaire (MSQ). RESULTS:Patients with a DLQI score > 5 (n = 990) were younger, had an earlier onset of psoriasis, scored higher on the Psoriasis Area and Severity Index (PASI), had higher body surface area (BSA) and had higher PASE scores than patients with DLQI ≤ 5 (n = 266). The group of patients with exposed lesions (n = 871) were younger and male predominance, earlier onset of psoriasis, longer disease duration, higher PASI/BSA score and a higher proportion with drinking and smoking history each than the group of patients without exposed lesions (n = 389). Presence of exposed lesions negatively influenced DLQI, 36-Item Short-Form Health Survey (SF-36) (mental component), presenteeism, total work productivity impairment and total activity impairment in the WPAI: PSO. In multiple regression model, PASI score was the only variable which was significantly associated with all HRQoL measures. Presence of exposed lesions was a significant factor affecting DLQI and SF-36 (mental). CONCLUSION: The presence of exposed lesions has a negative impact on quality of life, mental health and work productivity. Therefore, effective treatments are particularly needed for psoriasispatients with exposed lesions.
Authors: Lei Wei; Siting Chen; Zhan Zhang; Le Kuai; Rui Zhang; Ning Yu; Yuling Shi; Bin Li; Ruiping Wang Journal: Front Med (Lausanne) Date: 2022-05-12