M Zamani1,2, F Ebrahimtabar1, V Zamani3, W H Miller4, R Alizadeh-Navaei5, J Shokri-Shirvani6, M H Derakhshan7. 1. Student Research Committee, School of Medicine, Babol University of Medical Sciences, Babol, Iran. 2. Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. 3. Vice-Chancellery for Health, Babol University of Medical Sciences, Babol, Iran. 4. Faculty of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK. 5. Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran. 6. Department of Internal Medicine, Rohani Hospital, Babol University of Medical Sciences, Babol, Iran. 7. College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
Abstract
BACKGROUND: The epidemiology of Helicobacter pylori infection is poorly understood. AIM: To establish the reported regional and national prevalence of H. pylori infection, stratified by age and gender. METHODS: All relevant English publications from 2000 to 2017 cited by PubMed and Scopus were retrieved using comprehensive combinations of keywords. The overall prevalence of H. pylori was estimated using both random effect and fixed effect meta-analyses, and presented as prevalence rate (% and 95% CI). The analyses were extended by separation into gender and age groups. RESULTS: A total of 14 056 records were obtained initially. After applying exclusion criteria in several steps, 183 studies were selected. Analysis of 410 879 participants from 73 countries in six continents revealed an overall prevalence of 44.3% (95% CI: 40.9-47.7) worldwide. This rate ranged from 50.8% (95% CI: 46.8-54.7) in developing countries compared with 34.7% (95% CI: 30.2-39.3) in developed countries. The global H. pylori infection rate was 42.7% (95% CI: 39-46.5) in females compared to 46.3% (95% CI: 42.1-50.5) in males. The prevalence in adults (≥18 years) was significantly higher than in children (48.6% [95% CI: 43.8-53.5] vs 32.6% [95% CI: 28.4-36.8], respectively). There was a statistically nonsignificant decrease in the prevalence in 2009-2016 compared with the 2000-2009 period. CONCLUSIONS: The observed differences between countries appear to be due to economic and social conditions. H. pylori infection can be a benchmark for the socioeconomic and health status of a country. Further studies are suggested to investigate the natural history of the acquisition of H. pylori infection from childhood into adult life.
BACKGROUND: The epidemiology of Helicobacter pylori infection is poorly understood. AIM: To establish the reported regional and national prevalence of H. pyloriinfection, stratified by age and gender. METHODS: All relevant English publications from 2000 to 2017 cited by PubMed and Scopus were retrieved using comprehensive combinations of keywords. The overall prevalence of H. pylori was estimated using both random effect and fixed effect meta-analyses, and presented as prevalence rate (% and 95% CI). The analyses were extended by separation into gender and age groups. RESULTS: A total of 14 056 records were obtained initially. After applying exclusion criteria in several steps, 183 studies were selected. Analysis of 410 879 participants from 73 countries in six continents revealed an overall prevalence of 44.3% (95% CI: 40.9-47.7) worldwide. This rate ranged from 50.8% (95% CI: 46.8-54.7) in developing countries compared with 34.7% (95% CI: 30.2-39.3) in developed countries. The global H. pyloriinfection rate was 42.7% (95% CI: 39-46.5) in females compared to 46.3% (95% CI: 42.1-50.5) in males. The prevalence in adults (≥18 years) was significantly higher than in children (48.6% [95% CI: 43.8-53.5] vs 32.6% [95% CI: 28.4-36.8], respectively). There was a statistically nonsignificant decrease in the prevalence in 2009-2016 compared with the 2000-2009 period. CONCLUSIONS: The observed differences between countries appear to be due to economic and social conditions. H. pyloriinfection can be a benchmark for the socioeconomic and health status of a country. Further studies are suggested to investigate the natural history of the acquisition of H. pyloriinfection from childhood into adult life.
Authors: Estelle Guiard; Bénédicte Lelievre; Magali Rouyer; Frank Zerbib; Bertrand Diquet; Francis Mégraud; François Tison; Emmanuelle Bignon; Régis Lassalle; Cécile Droz-Perroteau; Nicholas Moore; Patrick Blin Journal: Drug Saf Date: 2019-08 Impact factor: 5.606