| Literature DB >> 294292 |
Abstract
A curvilinear dose response of myeloid leukaemia induction in the CBA male mouse was obtained after single whole-body X-irradiation at about 3 months of age. This strain has a very low spontaneous incidence of the disease and no cases were found in the unirradiated controls. The incidence was independent of dose rate over the range used (4.2-552 rad/min). Diagnosis required histopathological examination of various body tissues, the gross anatomical changes being easily confused with other haemopoietic disorders, but a few cases were recognized in life from blood samples. Curve-fitting to various models based on theories of radiocarcinogenic mechanism is described.Entities:
Mesh:
Year: 1979 PMID: 294292 PMCID: PMC2010144 DOI: 10.1038/bjc.1979.284
Source DB: PubMed Journal: Br J Cancer ISSN: 0007-0920 Impact factor: 7.640