Aynur Sahin1, Suha Turkmen2, Nizamettin Guzel3, Ahmet Mentese4, Suleyman Turedi1, Suleyman Caner Karahan4, Esin Yulug5, Selim Demir6, Osman Aynaci3, Orhan Deger4, Abdulkadir Gunduz1. 1. Department of Emergency Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. 2. Department of Emergency Medicine, Faculty of Medicine, Acıbadem University, Istanbul, Turkey. 3. Department of Orthopaedics and Traumatology, Samsun Training and Research Hospital, Samsun, Turkey. 4. Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey. 5. Department of Histology and Embryology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. 6. Department of Nutrition and Dietetics, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, Turkey.
Abstract
OBJECTIVES: Delayed healing and non-union of fractures have a significant effect upon patient morbidity. Studies have therefore largely concentrated on accelerating fracture healing. This study was intended to compare the effect of "mad honey" and propolis on fracture healing using radiological and histopathological analysis. SUBJECTS AND METHODS: Femur fracture was surgically performed on 48 rats, followed by fixation. Animals were then divided into 8 groups: 2 control groups (15- and 30-day) and 6 treatment groups (15- and 30-day normal honey, 15- and 30-day "mad honey," and 15- and 30-day propolis). Rats were sacrificed at the end of these periods, and radiological and histological examinations were performed. RESULTS: Radiological healing in the propolis group after 15-day therapy was statistically better than in the control (p = 0.004) and normal honey (p = 0.006) groups. After 30-day therapy, healing in the propolis group (p = 0.005) and grayanotoxin-containing "mad honey" group (p = 0.007) were significantly better than in the control group. Histologically, there was a statistically significant difference between the 15-day propolis group and the other groups (control, honey, mad honey: p = 0.003, p = 0.003, and p = 0.002, respectively). We also found a statistically significant difference when the 30-day propolis group (p = 0.005) and "mad honey" group (p = 0.007) were compared to the control group. CONCLUSIONS: This study shows that grayanotoxin-containing "mad honey" and propolis can accelerate fracture healing.
OBJECTIVES: Delayed healing and non-union of fractures have a significant effect upon patient morbidity. Studies have therefore largely concentrated on accelerating fracture healing. This study was intended to compare the effect of "mad honey" and propolis on fracture healing using radiological and histopathological analysis. SUBJECTS AND METHODS: Femur fracture was surgically performed on 48 rats, followed by fixation. Animals were then divided into 8 groups: 2 control groups (15- and 30-day) and 6 treatment groups (15- and 30-day normal honey, 15- and 30-day "mad honey," and 15- and 30-day propolis). Rats were sacrificed at the end of these periods, and radiological and histological examinations were performed. RESULTS: Radiological healing in the propolis group after 15-day therapy was statistically better than in the control (p = 0.004) and normal honey (p = 0.006) groups. After 30-day therapy, healing in the propolis group (p = 0.005) and grayanotoxin-containing "mad honey" group (p = 0.007) were significantly better than in the control group. Histologically, there was a statistically significant difference between the 15-day propolis group and the other groups (control, honey, mad honey: p = 0.003, p = 0.003, and p = 0.002, respectively). We also found a statistically significant difference when the 30-day propolis group (p = 0.005) and "mad honey" group (p = 0.007) were compared to the control group. CONCLUSIONS: This study shows that grayanotoxin-containing "mad honey" and propolis can accelerate fracture healing.
Authors: O Tatli; Y Karaca; S Turkmen; G S Gulgen; A Sahin; U Eryigit; O Fazli; E Karaguzel; A Mentese; A Orem; A Cansu; S Turedi; A Gunduz Journal: Bratisl Lek Listy Date: 2016 Impact factor: 1.278
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