Gayan Bowatte1, Caroline J Lodge2, Luke D Knibbs3, Bircan Erbas4, Jennifer L Perret2, Bin Jalaludin5, Geoffrey G Morgan6, Dinh S Bui2, Graham G Giles7, Garun S Hamilton8, Richard Wood-Baker9, Paul Thomas10, Bruce R Thompson11, Melanie C Matheson2, Michael J Abramson12, E Haydn Walters13, Shyamali C Dharmage14. 1. Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population & Global Health, The University of Melbourne, Melbourne, Australia; National Institute of Fundamental Studies, Kandy, Sri Lanka. 2. Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population & Global Health, The University of Melbourne, Melbourne, Australia. 3. School of Public Health, The University of Queensland, Brisbane, Australia. 4. School of Psychology & Public Health, Department of Public Health, Latrobe University, Melbourne, Australia. 5. Health People and Places Unit, South Western Sydney Local Health District, New South Wales, Sydney, Australia. 6. University Centre for Rural Health, School of Public Health, University of Sydney, New South Wales, Sydney, Australia. 7. Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population & Global Health, The University of Melbourne, Melbourne, Australia; Cancer Epidemiology Center, Cancer Council Victoria, Melbourne, Australia; School of Public Health & Preventive Medicine, Monash University, Melbourne, Australia. 8. Monash Lung and Sleep, Monash Health, Melbourne, Australia; School of Clinical Sciences, Monash University, Melbourne, Australia. 9. School of Medicine, University of Tasmania Medical School, Hobart, Australia. 10. POWHCS & IIRC, Faculty of Medicine, University of New South Wales, Sydney, Australia. 11. Allergy Immunology and Respiratory Medicine, Alfred Health, Central Clinical School, Monash University, Melbourne, Australia. 12. School of Public Health & Preventive Medicine, Monash University, Melbourne, Australia. 13. NHMRC CRE, University of Tasmania Medical School, Hobart, Australia. 14. Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population & Global Health, The University of Melbourne, Melbourne, Australia; Murdoch Childrens Research Institute, Melbourne, Australia. Electronic address: s.dharmage@unimelb.edu.au.
Abstract
BACKGROUND AND AIMS: Traffic Related Air Pollution (TRAP) exposure is known to exacerbate existing respiratory diseases. We investigated longer term effects of TRAP exposure for individuals with or without existing asthma, and with or without lower lung function. METHODS: Associations between TRAP exposure and asthma (n = 689) and lung function (n = 599) were investigated in the prospective Tasmanian Longitudinal Health Study (TAHS). TRAP exposure at age 45 years was measured using two methods based on residential address: mean annual NO2 exposure; and distance to nearest major road. Adjusted multinomial logistic regression was used to model the association between exposure to TRAP at 45 years and changes in asthma and lung function, using three follow ups of TAHS (45, 50 and 53 years). RESULTS: For those who never had asthma by 45, living <200 m from a major road was associated with increased odds of new asthma that persisted from 50 to 53 years (adjusted Odds Ratio [aOR] 5.20; 95% CI 1.07, 25.4). Asthmatic participants at 45 had an increased risk of persistent asthma up to 53 years if they were living <200 m from a major road, compared with asthmatic participants living >200 m from a major road (aOR = 5.21; 95% CI 1.54, 17.6). CONCLUSION: For middle aged adults, living <200 m for a major road (a marker of TRAP exposure) influences both the development and persistence of asthma. These findings have public health implications for asthma prevention strategies in primary and secondary settings.
BACKGROUND AND AIMS: Traffic Related Air Pollution (TRAP) exposure is known to exacerbate existing respiratory diseases. We investigated longer term effects of TRAP exposure for individuals with or without existing asthma, and with or without lower lung function. METHODS: Associations between TRAP exposure and asthma (n = 689) and lung function (n = 599) were investigated in the prospective Tasmanian Longitudinal Health Study (TAHS). TRAP exposure at age 45 years was measured using two methods based on residential address: mean annual NO2 exposure; and distance to nearest major road. Adjusted multinomial logistic regression was used to model the association between exposure to TRAP at 45 years and changes in asthma and lung function, using three follow ups of TAHS (45, 50 and 53 years). RESULTS: For those who never had asthma by 45, living <200 m from a major road was associated with increased odds of new asthma that persisted from 50 to 53 years (adjusted Odds Ratio [aOR] 5.20; 95% CI 1.07, 25.4). Asthmatic participants at 45 had an increased risk of persistent asthma up to 53 years if they were living <200 m from a major road, compared with asthmatic participants living >200 m from a major road (aOR = 5.21; 95% CI 1.54, 17.6). CONCLUSION: For middle aged adults, living <200 m for a major road (a marker of TRAP exposure) influences both the development and persistence of asthma. These findings have public health implications for asthma prevention strategies in primary and secondary settings.
Authors: Sheena E Martenies; Joshua P Keller; Sherry WeMott; Grace Kuiper; Zev Ross; William B Allshouse; John L Adgate; Anne P Starling; Dana Dabelea; Sheryl Magzamen Journal: Environ Sci Technol Date: 2021-02-17 Impact factor: 9.028
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