| Literature DB >> 29427645 |
Zhiqiang Ma1, Zhenlong Xin2, Wei Hu3, Shuai Jiang4, Zhi Yang5, Xiaolong Yan6, Xiaofei Li6, Yang Yang7, Fulin Chen8.
Abstract
The epithelial-mesenchymal transition (EMT) is an acknowledged cellular transition process in which epithelial cells acquire mesenchymal-like properties that endow cancer cells with increased migratory and invasive behavior. Forkhead box O (FOXO) proteins have been shown to orchestrate multiple EMT-associated pathways and EMT-related transcription factors (EMT-TFs), thereby modulating the EMT process. The focus of the current review is to evaluate the latest research progress regarding the roles of FOXO proteins in cancer EMT. First, a brief overview of the EMT process in cancer and a general background on the FOXO family are provided. Next, we present the interactions between FOXO proteins and multiple EMT-associated pathways during malignancy development. Finally, we propose several novel potential directions for future research. Collectively, the information compiled herein should serve as a comprehensive repository of information on this topic and should aid in the design of additional studies and the future development of FOXO proteins as therapeutic targets.Entities:
Keywords: Cancer; Epithelial-mesenchymal transition; Forkhead box O
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Year: 2018 PMID： 29427645 DOI： 10.1016/j.semcancer.2018.02.004
Source DB: PubMed Journal: Semin Cancer Biol ISSN： 1044-579X Impact factor: 15.707