Noa Lavi1, Irit Avivi2,3, Zipora Kra-Oz4,5, Ilana Oren5,6, Emilia Hardak7,8. 1. Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel. 2. Department of Hematology and Bone Marrow Transplantation, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. 3. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 4. Virology Laboratory, Rambam Health Care Campus, Haifa, Israel. 5. Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel. 6. Infectious Diseases Unit, Rambam Health Care Campus, Haifa, Israel. 7. Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel. e_hardak@rambam.health.gov.il. 8. Division of Pulmonary Medicine, Rambam Health Care Campus, 8, Ha'Aliya St., 31096, Haifa, Israel. e_hardak@rambam.health.gov.il.
Abstract
PURPOSE: Available data suggest that respiratory infections are associated with increased morbidity and mortality in patients hospitalized due to acute leukemia and allogeneic stem cell transplantation (allo-SCT). However, the precise incidence, risk factors, and severity of respiratory infection, mainly community-acquired, in patients with lymphoma and multiple myeloma (MM) are not fully determined. The current study aimed to investigate risk factors for respiratory infections and their clinical significance in patients with B cell non-Hodgkin lymphoma (NHL) and multiple myeloma (MM) in the first year of diagnosis. METHODS: Data of consecutive patients diagnosed with NHL or MM and treated at the Rambam Hematology Inpatient and Outpatient Units between 01/2011 and 03/2012 were evaluated. Information regarding anticancer treatment, incidence and course of respiratory infections, and infection-related outcomes was analyzed. RESULTS: One hundred and sixty episodes of respiratory infections were recorded in 103 (49%) of 211 (73-MM, 138-NHL) patients; 126 (79%) episodes were community-acquired, 47 (29%) of them required hospitalization. In univariate analysis, age < 60 years, MM diagnosis, and autologous SCT increased the respiratory infection risk (P = 0.058, 0.038, and 0.001, respectively). Ninety episodes (56% of all respiratory episodes) were examined for viral pathogens. Viral infections were documented in 25/90 (28%) episodes, 21 (84%) of them were community-acquired, requiring hospitalization in 5 (24%) cases. Anti-flu vaccination was performed in 119 (56%) patients. Two of the six patients diagnosed with influenza were vaccinated. CONCLUSIONS: Respiratory infections, including viral ones, are common in NHL and MM. Most infections are community-acquired and have a favorable outcome. Rapid identification of viral pathogens allows avoiding antibiotic overuse in this patient population.
PURPOSE: Available data suggest that respiratory infections are associated with increased morbidity and mortality in patients hospitalized due to acute leukemia and allogeneic stem cell transplantation (allo-SCT). However, the precise incidence, risk factors, and severity of respiratory infection, mainly community-acquired, in patients with lymphoma and multiple myeloma (MM) are not fully determined. The current study aimed to investigate risk factors for respiratory infections and their clinical significance in patients with B cell non-Hodgkin lymphoma (NHL) and multiple myeloma (MM) in the first year of diagnosis. METHODS: Data of consecutive patients diagnosed with NHL or MM and treated at the Rambam Hematology Inpatient and Outpatient Units between 01/2011 and 03/2012 were evaluated. Information regarding anticancer treatment, incidence and course of respiratory infections, and infection-related outcomes was analyzed. RESULTS: One hundred and sixty episodes of respiratory infections were recorded in 103 (49%) of 211 (73-MM, 138-NHL) patients; 126 (79%) episodes were community-acquired, 47 (29%) of them required hospitalization. In univariate analysis, age < 60 years, MM diagnosis, and autologous SCT increased the respiratory infection risk (P = 0.058, 0.038, and 0.001, respectively). Ninety episodes (56% of all respiratory episodes) were examined for viral pathogens. Viral infections were documented in 25/90 (28%) episodes, 21 (84%) of them were community-acquired, requiring hospitalization in 5 (24%) cases. Anti-flu vaccination was performed in 119 (56%) patients. Two of the six patients diagnosed with influenza were vaccinated. CONCLUSIONS:Respiratory infections, including viral ones, are common in NHL and MM. Most infections are community-acquired and have a favorable outcome. Rapid identification of viral pathogens allows avoiding antibiotic overuse in this patient population.
Authors: U Hohenthal; J Nikoskelainen; R Vainionpää; R Peltonen; M Routamaa; M Itälä; P Kotilainen Journal: Bone Marrow Transplant Date: 2001-02 Impact factor: 5.483
Authors: Lars Ohrmalm; Michelle Wong; Carl Aust; Per Ljungman; Oscar Norbeck; Kristina Broliden; Thomas Tolfvenstam Journal: PLoS One Date: 2012-05-03 Impact factor: 3.240
Authors: Gordon Cook; A John Ashcroft; Guy Pratt; Rakesh Popat; Karthik Ramasamy; Martin Kaiser; Matthew Jenner; Sarah Henshaw; Rachel Hall; Jonathan Sive; Simon Stern; Matthew Streetly; Ceri Bygrave; Richard Soutar; Neil Rabin; Graham H Jackson Journal: Br J Haematol Date: 2020-06-10 Impact factor: 8.615