Vlasta Bari1, Marco Ranucci1, Beatrice De Maria2, Beatrice Cairo3, Valeria Pistuddi1, Alberto Porta4. 1. Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy. 2. IRCCS Istituti Clinici Scientifici Maugeri, Istituto di Milano, Milan, Italy. 3. Department of Biomedical Sciences for Health, University of Milan, Milan, Italy. 4. Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy; Department of Biomedical Sciences for Health, University of Milan, Milan, Italy. Electronic address: alberto.porta@unimi.it.
Abstract
BACKGROUND: Postoperative atrial fibrillation (AF) might be favored by cardiovascular control impairment. We hypothesize that cardiovascular regulation indexes derived from directional model-based analysis of the spontaneous fluctuations of heart period (HP) and systolic arterial pressure (SAP) can identify subjects at risk to develop AF after coronary artery bypass graft (CABG) surgery. METHODS: Beat-to-beat HP and SAP series were derived from electrocardiogram (ECG) and invasive arterial pressure recorded for 5 min just before CABG surgery in conscious condition. The group comprised subjects who did develop AF (AF, n = 37, 71 ± 8 years, 27 males) or did not (noAF, n = 92, 65 ± 10 years, 85 males). From HP and SAP variabilities we computed classical time-domain, spectral, cross-spectral and complexity indexes characterizing autonomic function and cardiac baroreflex control. Moreover, we performed model-based directional analysis assessing the gain and strength of the relations from SAP to HP along cardiac baroreflex feedback and from HP to SAP along the feedforward pathway while disambiguating the effect of respiration as estimated from respiratory-related ECG modulations. RESULTS: Classical HP and SAP variability indexes and baroreflex sensitivity could not separate AF from noAF individuals. Causality markers, and more specifically, the strength of the dynamical interactions from SAP to HP and vice versa, could distinguish the two groups: indeed, AFs have a lower degree of association from SAP to HP and vice versa. CONCLUSIONS: An impairment of the feedforward and feedback arms of the HP-SAP closed loop relation predisposes subjects undergoing CABG surgery to develop postoperative AF. PERSPECTIVES: Competency in medical knowledge: Atrial fibrillation (AF) is a frequent complication after coronary artery bypass graft (CABG) surgery lengthening hospitalization duration and increasing healthcare system costs. Translational outlook 1: CABG patients who developed AF had a less preserved cardiovascular interactions due to less active physiological control mechanisms as resulting from the lower degree of dependence of systolic arterial pressure on heart period and vice versa before CABG surgery. Translational outlook 2: Cardiovascular control markers improve stratification of the AF risk after CABG surgery above and beyond more traditional demographic and clinical indexes.
BACKGROUND:Postoperative atrial fibrillation (AF) might be favored by cardiovascular control impairment. We hypothesize that cardiovascular regulation indexes derived from directional model-based analysis of the spontaneous fluctuations of heart period (HP) and systolic arterial pressure (SAP) can identify subjects at risk to develop AF after coronary artery bypass graft (CABG) surgery. METHODS: Beat-to-beat HP and SAP series were derived from electrocardiogram (ECG) and invasive arterial pressure recorded for 5 min just before CABG surgery in conscious condition. The group comprised subjects who did develop AF (AF, n = 37, 71 ± 8 years, 27 males) or did not (noAF, n = 92, 65 ± 10 years, 85 males). From HP and SAP variabilities we computed classical time-domain, spectral, cross-spectral and complexity indexes characterizing autonomic function and cardiac baroreflex control. Moreover, we performed model-based directional analysis assessing the gain and strength of the relations from SAP to HP along cardiac baroreflex feedback and from HP to SAP along the feedforward pathway while disambiguating the effect of respiration as estimated from respiratory-related ECG modulations. RESULTS: Classical HP and SAP variability indexes and baroreflex sensitivity could not separate AF from noAF individuals. Causality markers, and more specifically, the strength of the dynamical interactions from SAP to HP and vice versa, could distinguish the two groups: indeed, AFs have a lower degree of association from SAP to HP and vice versa. CONCLUSIONS: An impairment of the feedforward and feedback arms of the HP-SAP closed loop relation predisposes subjects undergoing CABG surgery to develop postoperative AF. PERSPECTIVES: Competency in medical knowledge: Atrial fibrillation (AF) is a frequent complication after coronary artery bypass graft (CABG) surgery lengthening hospitalization duration and increasing healthcare system costs. Translational outlook 1: CABG patients who developed AF had a less preserved cardiovascular interactions due to less active physiological control mechanisms as resulting from the lower degree of dependence of systolic arterial pressure on heart period and vice versa before CABG surgery. Translational outlook 2: Cardiovascular control markers improve stratification of the AF risk after CABG surgery above and beyond more traditional demographic and clinical indexes.
Authors: Vlasta Bari; Emanuele Vaini; Valeria Pistuddi; Angela Fantinato; Beatrice Cairo; Beatrice De Maria; Laura Adelaide Dalla Vecchia; Marco Ranucci; Alberto Porta Journal: Front Physiol Date: 2019-10-18 Impact factor: 4.566