Ali Sharifi-Rigi1, Esfandiar Heidarian2, Sayed Asadollah Amini3. 1. a Student Research Committee , Shahrekord University of Medical Sciences , Shahrekord , Iran. 2. b Clinical Biochemistry Research Center, Basic Health Sciences Institute , Shahrekord University of Medical Sciences , Shahrekord , Iran. 3. c Medical Plants Research Center, Basic Health Sciences Institute , Shahrekord University of Medical Sciences , Shahrekord , Iran.
Abstract
CONTEXT: Toxicity with paraquat can lead to serious damages to the liver. OBJECTIVE: The study investigates the protective effects of Origanum vulgare leaf extract against paraquat liver damage. MATERIAL AND METHODS: Rats were divided into six groups. Group 1, the control group; group 2, rats that received paraquat only; group 3, rats that received paraquat plus silymarin; and groups 4, 5, and 6 were treated with paraquat and O. vulgare leaf extract. Then, the serum and tissue parameters of the oxidative stress were examined. RESULTS: In group 2, paraquat caused a remarkable increase in the level of serum ALT, AST, ALP, lipid profiles, and liver TNF-α gene expression compared to group 1. The groups which received O. vulgare leaf extract exhibited significant ameliorations in abnormalities of paraquat-induced liver damage and serum biochemical parameters. CONCLUSION: O. vulgare leaf extract has inhibitory effects on paraquat-induced liver damage due to its antioxidant properties.
CONTEXT: Toxicity with paraquat can lead to serious damages to the liver. OBJECTIVE: The study investigates the protective effects of Origanum vulgare leaf extract against paraquatliver damage. MATERIAL AND METHODS:Rats were divided into six groups. Group 1, the control group; group 2, rats that received paraquat only; group 3, rats that received paraquat plus silymarin; and groups 4, 5, and 6 were treated with paraquat and O. vulgare leaf extract. Then, the serum and tissue parameters of the oxidative stress were examined. RESULTS: In group 2, paraquat caused a remarkable increase in the level of serum ALT, AST, ALP, lipid profiles, and liver TNF-α gene expression compared to group 1. The groups which received O. vulgare leaf extract exhibited significant ameliorations in abnormalities of paraquat-induced liver damage and serum biochemical parameters. CONCLUSION:O. vulgare leaf extract has inhibitory effects on paraquat-induced liver damage due to its antioxidant properties.