Francis Renault1, Roberto Flores-Guevara2, Bernard Sergent3, Jean Jacques Baudon4, Jessie Aouizerate5, Marie-Paule Vazquez6, Cyril Gitiaux7. 1. Centre de référence des malformations rares de la face et de la cavité buccale MAFACE, Hôpital Necker-Enfants-Malades, Paris, France. 2. Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru. 3. Service de chirurgie maxillo-faciale et chirurgie plastique de l'enfant, Hôpital Necker-Enfants-Malades, Paris, France. 4. Faculté de médecine Pierre et Marie Curie, université Paris 6, Paris, France. 5. Département d'histologie, Hôpital Henri-Mondor, Créteil, France. 6. Faculté de médecine Paris Descartes, université Paris 5, Paris, France. 7. Service de neurophysiologie clinique pédiatrique & centre de référence des maladies neuromusculaires, Hôpital Necker-Enfants-Malades, Paris, France.
Abstract
INTRODUCTION: We designed a retrospective study of 59 patients with congenital sporadic nonprogressive bilateral facial and abducens palsies. METHODS: Examinations included needle electromyography (EMG) of facial and oral muscles, facial nerve motor latency and conduction velocity (FNCV), and blink responses (BR). RESULTS: Neurogenic EMG changes were found in 1 or more muscles in 55 of 59 patients, with no abnormal spontaneous activity. EMG changes were homogeneously neurogenic in 17 patients, homogeneously myopathic in 1 patient, and heterogeneous in 41 of 59 patients. Motor latency was increased according to recordings from 52 of 137 facial muscles. An increase of motor latency was not associated with neurogenic EMG (Fischer's test: right, P = 1; left, P = 0.76). FNCV was slowed in 19 of 36 patients. BR was absent bilaterally in 35 of 58 patients; when present, R1 and R2 latencies were normal. DISCUSSION: Our results support the hypothesis of an early developmental defect localized in motor cranial nerves with spared V-VII internuclear pathways. Muscle Nerve, 2018.
INTRODUCTION: We designed a retrospective study of 59 patients with congenital sporadic nonprogressive bilateral facial and abducens palsies. METHODS: Examinations included needle electromyography (EMG) of facial and oral muscles, facial nerve motor latency and conduction velocity (FNCV), and blink responses (BR). RESULTS: Neurogenic EMG changes were found in 1 or more muscles in 55 of 59 patients, with no abnormal spontaneous activity. EMG changes were homogeneously neurogenic in 17 patients, homogeneously myopathic in 1 patient, and heterogeneous in 41 of 59 patients. Motor latency was increased according to recordings from 52 of 137 facial muscles. An increase of motor latency was not associated with neurogenic EMG (Fischer's test: right, P = 1; left, P = 0.76). FNCV was slowed in 19 of 36 patients. BR was absent bilaterally in 35 of 58 patients; when present, R1 and R2 latencies were normal. DISCUSSION: Our results support the hypothesis of an early developmental defect localized in motor cranial nerves with spared V-VII internuclear pathways. Muscle Nerve, 2018.
Authors: Tanya Lehky; Reversa Joseph; Camilo Toro; Tianxia Wu; Carol Van Ryzin; Andrea Gropman; Flavia M Facio; Bryn D Webb; Ethylin W Jabs; Brenda S Barry; Elizabeth C Engle; Francis S Collins; Irini Manoli Journal: Muscle Nerve Date: 2021-01-19 Impact factor: 3.217