Asif Ahmed1, Joshua Boateng1. 1. Department of Pharmaceutical, Chemical & Environmental Sciences, Faculty of Engineering & Science, University of Greenwich, Medway, Central Ave Chatham Maritime, Kent, ME4 4TB, UK.
Abstract
AIM: Diabetic foot ulcers are susceptible to infection and nonmedicated dressings are ineffective because they have no antimicrobial activity. This study aimed to develop antimicrobial films to deliver ciprofloxacin for treating bacterial infection. Results/methodology: Ciprofloxacin-loaded calcium alginate films were characterized for porosity, swelling, equilibrium water content, water absorption, water vapor transmission, evaporative water loss, moisture content, mechanical strength, adhesion, IR spectroscopy, scanning electron microscopy, x-ray diffraction, drug release, cytotoxicity and antimicrobial activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Films were transparent, flexible, uniform, with ideal moisture handling, maximum drug release within 90 min, killing bacteria within 24 h and highly biocompatible with human keratinocyte cells. CONCLUSION: The results confirmed successful design of biocompatible dressings effective against Gram-positive and Gram-negative bacteria. [Formula: see text].
AIM: Diabetic foot ulcers are susceptible to infection and nonmedicated dressings are ineffective because they have no antimicrobial activity. This study aimed to develop antimicrobial films to deliver ciprofloxacin for treating bacterial infection. Results/methodology: Ciprofloxacin-loaded calcium alginate films were characterized for porosity, swelling, equilibrium water content, water absorption, water vapor transmission, evaporative water loss, moisture content, mechanical strength, adhesion, IR spectroscopy, scanning electron microscopy, x-ray diffraction, drug release, cytotoxicity and antimicrobial activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Films were transparent, flexible, uniform, with ideal moisture handling, maximum drug release within 90 min, killing bacteria within 24 h and highly biocompatible with human keratinocyte cells. CONCLUSION: The results confirmed successful design of biocompatible dressings effective against Gram-positive and Gram-negative bacteria. [Formula: see text].
Authors: Rosemond A Mensah; Seung Bin Jo; Hoon Kim; Sung-Min Park; Kapil D Patel; Kyong J Cho; Michael T Cook; Stewart B Kirton; Victoria Hutter; Laura E Sidney; Decio Alves-Lima; Hungyen Lin; Jung-Hwan Lee; Hae-Won Kim; David Ys Chau Journal: J Biomater Appl Date: 2021-06-18 Impact factor: 2.646