| Literature DB >> 29423995 |
Yangzhouyun Xie1,2, Yong Liu1,2, Junchuan Yang1, Yuan Liu3, Fupin Hu4, Kui Zhu3, Xingyu Jiang1,2.
Abstract
Widespread multidrug resistance caused by the abuse of antibiotics calls for novel strategies and materials. Gold nanoclusters (AuNCs) are scarcely explored for combating multidrug-resistant (MDR) bacteria in vivo. We herein synthesized a novel class of AuNCs, namely quaternary ammonium (QA) capped AuNCs (QA-AuNCs) as potent antibiotics selectively targeting MDR Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE), in vivo. QA-AuNCs kill bacteria through a combined physicochemical mechanism, and show excellent therapeutic effects in both a skin infection model and a bacteremia model induced by MRSA. In addition, owing to their intense fluorescence, QA-AuNCs can be used for the discrimination of live/dead bacteria and bacteria counting, suggesting their potential for clinical theranostics.Entities:
Keywords: Gram-positive bacteria; ammonium salts; antibiotics; drug resistance; gold nanoclusters
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Year: 2018 PMID： 29423995 DOI： 10.1002/anie.201712878
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336