Feng Gao 1 , Lin-Jie Xu 1 , Yuan Zhao 1 , Xing-Huai Sun 1 , Zhongfeng Wang 1 Show Affiliations »
Abstract
BACKGROUND & OBJECTIVE: Müller cell is the major type of glial cell in the vertebrate retina. Müller cells express various types of K+ channels, such as inwardly rectifying K+ (Kir) channels, big conductance Ca2+-activated K+ (BKCa) channels, delayed rectifier K+ channels (KDR), and transient A-type K+ channels. These K+ channels play important roles in maintaining physiological functions of Müller cells. Under some retinal pathological conditions, the changed expression and functions of K+ channels may contribute to retinal pathogenesis. CONCLUSION: In this article, we reviewed the physiological properties of K+ channels in retinal Müller cells and the functional changes of these channels in retinal disorders. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND & OBJECTIVE: Müller cell is the major type of glial cell in the vertebrate retina. Müller cells express various types of K+ channels, such as inwardly rectifying K+ (Kir ) channels, big conductance Ca2+-activated K+ (BKCa) channels, delayed rectifier K+ channels (KDR ), and transient A-type K+ channels. These K+ channels play important roles in maintaining physiological functions of Müller cells. Under some retinal pathological conditions, the changed expression and functions of K+ channels may contribute to retinal pathogenesis. CONCLUSION: In this article, we reviewed the physiological properties of K+ channels in retinal Müller cells and the functional changes of these channels in retinal disorders . Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Disease
Gene
Keywords:
A-type K+ channels; BKCa channels; KDR; Kir channels; Müller cells; retinal disorders.
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Year: 2018
PMID： 29422007 DOI： 10.2174/1871527317666180202114233
Source DB: PubMed Journal: CNS Neurol Disord Drug Targets ISSN： 1871-5273 Impact factor: 4.388