María Del Carmen Sierra Romero1, Eduardo Navarrete Hernández2, Sonia Canún Serrano3, Aldelmo E Reyes Pablo4, Javier Valdés Hernández5. 1. División de Genética, Hospital General Dr. Manuel Gea González, México D.F., México. Electronic address: ma_carmen_sierra@hotmail.com. 2. Investigación independiente, Coordinación de Vigilancia Epidemiológica, Instituto Mexicano del Seguro Social, México D.F., México. 3. Investigación independiente, Hospital General Dr. Manuel Gea González, México D.F., México. 4. División de Gineco-Obstetricia, Hospital General Dr. Manuel Gea González, México D.F., México. 5. Dirección General Adjunta de Epidemiología, Secretaría de Salud, México D.F., México.
Abstract
BACKGROUND: Down syndrome (DS) or trisomy 21 is the most common genetic cause of mental retardation with the clinical presentation of a series of well-defined characteristics. Advanced maternal age has been associated with DS. METHODS: The databases of all the certificates of live births and fetal deaths in Mexico were combined. Codes based on the International Classification of Diseases 10th Revision (ICD-10) in Chapter XVII "Congenital malformations, deformations and chromosomal abnormalities" were selected. RESULTS: A database of 8,250,375 births during the period 2008-2011 was constructed: 99.2% were live births with 0.8% of fetal deaths and 3,076 cases diagnosed with DS. CONCLUSIONS: The importance of this report is to initiate an epidemiological surveillance of newborn cases of DS nationwide and by state using census information systems available in the country since 2008. An increased risk has been observed for having a child with DS since the mother is ≥ 35 years, as has been reported in other studies.
BACKGROUND: Down syndrome (DS) or trisomy 21 is the most common genetic cause of mental retardation with the clinical presentation of a series of well-defined characteristics. Advanced maternal age has been associated with DS. METHODS: The databases of all the certificates of live births and fetal deaths in Mexico were combined. Codes based on the International Classification of Diseases 10th Revision (ICD-10) in Chapter XVII "Congenital malformations, deformations and chromosomal abnormalities" were selected. RESULTS: A database of 8,250,375 births during the period 2008-2011 was constructed: 99.2% were live births with 0.8% of fetal deaths and 3,076 cases diagnosed with DS. CONCLUSIONS: The importance of this report is to initiate an epidemiological surveillance of newborn cases of DS nationwide and by state using census information systems available in the country since 2008. An increased risk has been observed for having a child with DS since the mother is ≥ 35 years, as has been reported in other studies.
Keywords:
Certificado de muerte fetal; Certificado de nacimiento vivo; Down syndrome; Fetal death certificates; Live birth certificates; Prevalence; Prevalencia; Síndrome de Down; Trisomy 21; Trisomía 21
Authors: Mariana Rabello Laignier; Luís Carlos Lopes-Júnior; Raquel Esperidon Santana; Franciéle Marabotti Costa Leite; Carolina Laura Brancato Journal: Int J Environ Res Public Health Date: 2021-11-14 Impact factor: 3.390