Tobias Andersson1, Per Hjerpe2, Axel C Carlsson3, Aldina Pivodic4, Per Wändell5, Karin Manhem6, Kristina Bengtsson Boström7. 1. Närhälsan Norrmalm Health Centre, Ekängsvägen 15, 541 41 Skövde, Sweden; Department of Public Health and Community Medicine/Primary Health Care, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. Electronic address: tobias.e.andersson@vgregion.se. 2. Närhälsan R&D Centre Skaraborg Primary Care, Långgatan 18, 541 30 Skövde, Sweden. Electronic address: per.hjerpe@vgregion.se. 3. Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Alfred Nobels allé 23, D2, 141 83 Huddinge, Sweden. Electronic address: axelcefam@hotmail.com. 4. Statistiska Konsultgruppen, Stigbergsliden 5, 414 63 Göteborg, Sweden. Electronic address: aldina.pivodic@stat-grp.se. 5. Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Alfred Nobels allé 23, D2, 141 83 Huddinge, Sweden. Electronic address: per.wandell@ki.se. 6. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. Electronic address: karin.manhem@vgregion.se. 7. Närhälsan R&D Centre Skaraborg Primary Care, Långgatan 18, 541 30 Skövde, Sweden. Electronic address: kristina.a.bengtsson@vgregion.se.
Abstract
AIMS: Our aim was to assess causes of death and temporal changes in excess mortality among patients with new-onset type 2 diabetes in Skaraborg, Sweden. METHODS: Patients from the Skaraborg Diabetes Register with prospectively registered new-onset type 2 diabetes 1991-2004 were included. Five individual controls matched for sex, age, geographical area and calendar year of study entry were selected using population records. Causes of deaths until 31 December 2014 were retrieved from the Cause of Death Register. Adjusted excess mortality among patients and temporal changes of excess mortality were calculated using Poisson models. Cumulative incidences of cause-specific mortality were calculated by competing risk regression. RESULTS: During 24 years of follow-up 4364 deaths occurred among 7461 patients in 90,529 person-years (48.2/1000 person-years, 95% CI 46.8-49.7), and 18,541 deaths in 479,428 person-years among 37,271 controls (38.7/1000 person-years, 38.1-39.2). The overall adjusted mortality hazard ratio was 1.47 (p < .0001) among patients diagnosed at study start 1991 and decreased by 2% (p < .0001) per increase in calendar year of diagnosis until 2004. Excess mortality was mainly attributed to endocrine and cardiovascular cause of death with crude subdistributional hazard ratios of 5.06 (p < .001) and 1.22 (p < .001). CONCLUSIONS: Excess mortality for patients with new-onset type 2 diabetes was mainly attributed to deaths related to diabetes and the cardiovascular system, and decreased with increasing year of diagnosis 1991-2004. Possible explanations could be temporal trends of earlier diagnosis due to lowered diagnostic thresholds and intensified diagnostic activities, as well as improved treatment.
AIMS: Our aim was to assess causes of death and temporal changes in excess mortality among patients with new-onset type 2 diabetes in Skaraborg, Sweden. METHODS:Patients from the Skaraborg Diabetes Register with prospectively registered new-onset type 2 diabetes 1991-2004 were included. Five individual controls matched for sex, age, geographical area and calendar year of study entry were selected using population records. Causes of deaths until 31 December 2014 were retrieved from the Cause of Death Register. Adjusted excess mortality among patients and temporal changes of excess mortality were calculated using Poisson models. Cumulative incidences of cause-specific mortality were calculated by competing risk regression. RESULTS: During 24 years of follow-up 4364 deaths occurred among 7461 patients in 90,529 person-years (48.2/1000 person-years, 95% CI 46.8-49.7), and 18,541 deaths in 479,428 person-years among 37,271 controls (38.7/1000 person-years, 38.1-39.2). The overall adjusted mortality hazard ratio was 1.47 (p < .0001) among patients diagnosed at study start 1991 and decreased by 2% (p < .0001) per increase in calendar year of diagnosis until 2004. Excess mortality was mainly attributed to endocrine and cardiovascular cause of death with crude subdistributional hazard ratios of 5.06 (p < .001) and 1.22 (p < .001). CONCLUSIONS: Excess mortality for patients with new-onset type 2 diabetes was mainly attributed to deaths related to diabetes and the cardiovascular system, and decreased with increasing year of diagnosis 1991-2004. Possible explanations could be temporal trends of earlier diagnosis due to lowered diagnostic thresholds and intensified diagnostic activities, as well as improved treatment.
Authors: Lukas Sprenger; Arthur Mader; Barbara Larcher; Maximilian Mächler; Alexander Vonbank; Daniela Zanolin-Purin; Andreas Leiherer; Axel Muendlein; Heinz Drexel; Christoph H Saely Journal: BMJ Open Diabetes Res Care Date: 2021-11
Authors: Donata Linkeviciute-Ulinskiene; Auguste Kaceniene; Audrius Dulskas; Ausvydas Patasius; Lina Zabuliene; Giedre Smailyte Journal: Int J Environ Res Public Health Date: 2020-09-20 Impact factor: 3.390