José de Jesús Peralta Romero1, Roberto Karam Araujo2, Ana Isabel Burguete García3, Barbara Ixchel Estrada Velasco3, Claudia López Islas3, Paula María Del Carmen Figueroa Arredondo4, Adán Valladares Salgado5, Miguel Cruz6. 1. Department of Graduate Studies, National School of Medicine and Homeopathy, Section of Molecular Biomedicine, Instituto Politécnico Nacional, Mexico City, Mexico; Medical Research Unit in Biochemistry, Specialties Hospital, Centro Médico Nacional SXXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico. 2. Department of Economic and Social Benefits, Mexican Social Security Institute, Mexico City, Mexico. 3. Department of Chronic Infection and Cancer, CISEI, National Institute of Public Health , Cuernavaca, Morelos, Mexico. 4. Department of Graduate Studies, National School of Medicine and Homeopathy, Section of Molecular Biomedicine, Instituto Politécnico Nacional, Mexico City, Mexico. 5. Medical Research Unit in Biochemistry, Specialties Hospital, Centro Médico Nacional SXXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico. 6. Medical Research Unit in Biochemistry, Specialties Hospital, Centro Médico Nacional SXXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico. Electronic address: mcruzl@yahoo.com.
Abstract
BACKGROUND: ENSANUT 2012 showed a combined prevalence of overweight and obesity of 34.4% in Mexican children. Single nucleotide polymorphisms (SNPs) of the ADIPOQ and ADIPOR2 genes have been reported in many populations, but their association with obesity has not been confirmed in other studies. Our aim was to determine the association of SNPs from ADIPOQ and ADIPOR2 genes with obesity in Mexican children. METHODS: A total of 2,634 children from 6 to 12 years old were enrolled in the study from four IMSS Units in Mexico City. We selected 1,469 unrelated children (745 normal weight and 724 overweight/obese). Phenotype characterization included anthropometric measurements, blood pressure, biochemical parameters, insulin concentrations and presence of acanthosis nigricans (AN). Analysis of the SNPs rs182052, rs266729, rs2241766, rs822393 of ADIPOQ and rs11061971 of ADIPOR2 was carried out in the DNA samples. RESULTS: The study showed significant differences (p <0.05) between groups in waist circumference, blood pressure, presence of AN, insulin concentrations, HOMA-IR, fasting glucose and lipid parameters, being higher in obese children. No associations in ADIPOQ variants with the presence of overweight/obesity were found. The presence of the variant rs11061971 of ADIPOR2 in children had a significant association with protection of overweight/obesity (OR 0.79, 95% CI 0.68-0.93, p = 0.003). Also, the log-additive model confirmed the association by codominant and dominant models (p <0.05). CONCLUSIONS: The presence of rs11061971 of ADIPOR2 variant confers protection against obesity and could be used as a marker in Mexican children.
BACKGROUND: ENSANUT 2012 showed a combined prevalence of overweight and obesity of 34.4% in Mexican children. Single nucleotide polymorphisms (SNPs) of the ADIPOQ and ADIPOR2 genes have been reported in many populations, but their association with obesity has not been confirmed in other studies. Our aim was to determine the association of SNPs from ADIPOQ and ADIPOR2 genes with obesity in Mexican children. METHODS: A total of 2,634 children from 6 to 12 years old were enrolled in the study from four IMSS Units in Mexico City. We selected 1,469 unrelated children (745 normal weight and 724 overweight/obese). Phenotype characterization included anthropometric measurements, blood pressure, biochemical parameters, insulin concentrations and presence of acanthosis nigricans (AN). Analysis of the SNPs rs182052, rs266729, rs2241766, rs822393 of ADIPOQ and rs11061971 of ADIPOR2 was carried out in the DNA samples. RESULTS: The study showed significant differences (p <0.05) between groups in waist circumference, blood pressure, presence of AN, insulin concentrations, HOMA-IR, fasting glucose and lipid parameters, being higher in obesechildren. No associations in ADIPOQ variants with the presence of overweight/obesity were found. The presence of the variant rs11061971 of ADIPOR2 in children had a significant association with protection of overweight/obesity (OR 0.79, 95% CI 0.68-0.93, p = 0.003). Also, the log-additive model confirmed the association by codominant and dominant models (p <0.05). CONCLUSIONS: The presence of rs11061971 of ADIPOR2 variant confers protection against obesity and could be used as a marker in Mexican children.
Authors: Ana I Burguete-García; Alan Gilberto Ramírez Valverde; Meztli Espinoza-León; Isaac Sánchez Vázquez; Evelyn Yazmín Estrada Ramírez; Itzel Maldonado-López; Alfredo Lagunas Martínez; Cinthya Estefhany Diaz Benítez; Roberto Karam Araujo; Diana Fernández-Madinaveitia; Adriana E Anides Fonseca; Miguel Cruz; José de Jesús Peralta Romero Journal: Dermatol Res Pract Date: 2022-03-28