Literature DB >> 29420687

Intermittent mTOR Inhibition Reverses Kidney Aging in Old Rats.

Andrea Di Francesco1, Alberto Diaz-Ruiz1, Rafael de Cabo1, Michel Bernier1.   

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Year:  2018        PMID： 29420687      PMCID： PMC6001901          DOI： 10.1093/gerona/gly023

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN： 1079-5006            Impact factor:   6.053


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  11 in total

Review 1.  Strategies for the management of adverse events associated with mTOR inhibitors.

Authors:  Bruce Kaplan; Yasir Qazi; Jason R Wellen
Journal:  Transplant Rev (Orlando)       Date:  2014-03-12       Impact factor: 3.943

Review 2.  Regulation of immune responses by mTOR.

Authors:  Jonathan D Powell; Kristen N Pollizzi; Emily B Heikamp; Maureen R Horton
Journal:  Annu Rev Immunol       Date:  2011-11-29       Impact factor: 28.527

Review 3.  mTOR signaling and drug development in cancer.

Authors:  Janet Dancey
Journal:  Nat Rev Clin Oncol       Date:  2010-03-16       Impact factor: 66.675

4.  Sirolimus therapy predisposes to new-onset diabetes mellitus after renal transplantation: a long-term analysis of various treatment regimens.

Authors:  E Gyurus; Z Kaposztas; B D Kahan
Journal:  Transplant Proc       Date:  2011-06       Impact factor: 1.066

5.  mTOR inhibition improves immune function in the elderly.

Authors:  Joan B Mannick; Giuseppe Del Giudice; Maria Lattanzi; Nicholas M Valiante; Jens Praestgaard; Baisong Huang; Michael A Lonetto; Holden T Maecker; John Kovarik; Simon Carson; David J Glass; Lloyd B Klickstein
Journal:  Sci Transl Med       Date:  2014-12-24       Impact factor: 17.956

6.  Reduced expression of MYC increases longevity and enhances healthspan.

Authors:  Jeffrey W Hofmann; Xiaoai Zhao; Marco De Cecco; Abigail L Peterson; Luca Pagliaroli; Jayameenakshi Manivannan; Gene B Hubbard; Yuji Ikeno; Yongqing Zhang; Bin Feng; Xiaxi Li; Thomas Serre; Wenbo Qi; Holly Van Remmen; Richard A Miller; Kevin G Bath; Rafael de Cabo; Haiyan Xu; Nicola Neretti; John M Sedivy
Journal:  Cell       Date:  2015-01-22       Impact factor: 41.582

7.  Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue.

Authors:  Vanessa P Houde; Sophie Brûlé; William T Festuccia; Pierre-Gilles Blanchard; Kerstin Bellmann; Yves Deshaies; André Marette
Journal:  Diabetes       Date:  2010-03-18       Impact factor: 9.461

8.  Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins.

Authors:  Katherine H Schreiber; Denise Ortiz; Emmeline C Academia; Arieanna C Anies; Chen-Yu Liao; Brian K Kennedy
Journal:  Aging Cell       Date:  2015-02-04       Impact factor: 9.304

9.  Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.

Authors:  Sebastian I Arriola Apelo; Joshua C Neuman; Emma L Baar; Faizan A Syed; Nicole E Cummings; Harpreet K Brar; Cassidy P Pumper; Michelle E Kimple; Dudley W Lamming
Journal:  Aging Cell       Date:  2015-10-13       Impact factor: 9.304

10.  Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology.

Authors:  Tea Shavlakadze; Jiang Zhu; Sharon Wang; Weihua Zhou; Bret Morin; Marc A Egerman; Lin Fan; Yanqun Wang; Oleg Iartchouk; Angelika Meyer; Reginald A Valdez; Joan B Mannick; Lloyd B Klickstein; David J Glass
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2018-06-14       Impact factor: 6.053
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  3 in total

1.  Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity.

Authors:  Svetlana Ukraintseva; Konstantin Arbeev; Matt Duan; Igor Akushevich; Alexander Kulminski; Eric Stallard; Anatoliy Yashin
Journal:  Mech Ageing Dev       Date:  2020-12-16       Impact factor: 5.432

2.  C/EBPα deficiency in podocytes aggravates podocyte senescence and kidney injury in aging mice.

Authors:  Liwen Zhang; Fangfang Zhou; Xialian Yu; Yufei Zhu; Ying Zhou; Jian Liu; Yunzi Liu; Qingyang Ma; Yuchao Zhang; Weiming Wang; Nan Chen
Journal:  Cell Death Dis       Date:  2019-09-17       Impact factor: 8.469

Review 3.  Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging.

Authors:  Mengdi Yu; Hongxia Zhang; Brian Wang; Yinuo Zhang; Xiaoying Zheng; Bei Shao; Qichuan Zhuge; Kunlin Jin
Journal:  Cells       Date:  2021-03-16       Impact factor: 6.600
  3 in total

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