Fernando B Góngora1,2, Rosa F Chiriboga-Ponce3,4. 1. Hemocentro Nacional de la Cruz Roja. Quito, Ecuador. 2. Ministerio de Salud Pública del Ecuador. Quito, Ecuador. 3. Centro de Investigación para la salud en América Latina, Pontificia Universidad Católica del Ecuador. Quito, Ecuador. 4. Facultad de Medicina, Carrera de Bioquímica Clínica, Pontificia Universidad Católica del Ecuador. Quito, Ecuador.
Abstract
Introduction: The Diego blood group is an irregular blood system which has been involved in cases of hemolytic disease of the newborn and post transfusion reactions, in this system have been identified 22 erythrocyte antigens, among which the pair Dia/Dib is the most important because those have the most immunogenic potential. Objective: This research aims to determine the frequency of antigen Dia and their respective alloantibody in the Ecuadorian population. Methods: It was performed a simple random sampling in the donor population, being later tested tube agglutination by the presence or absence of the antigen and its alloantibody Dia applying gel agglutination technique. Results: It was observed an antigen prevalence of 25% against a 6.09% of percentage alloimmunization due to Dia antigen, without significant differences between men and women and these being independent of the age and origin of the donor, showing that there are some Diego positive cases in Ecuadorian population as probably cases of transfusional alloinmunization or due to fetal-maternal alloinmunization. Conclusions and Recommendations: The frequency distribution of antigens and alloantibodies from the Diego blood group is almost uniform in the population, due presumably to the high incidence of miscegenation in our country. Therefore it becomes vitally important the implementation of this blood system inside the protocols of irregular antibodies identification in Ecuadorian blood banks. Copyright:
Introduction: The Diego blood group is an irregular blood system which has been involved in cases of hemolytic disease of the newborn and post transfusion reactions, in this system have been identified 22 erythrocyte antigens, among which the pair Dia/Dib is the most important because those have the most immunogenic potential. Objective: This research aims to determine the frequency of antigen Dia and their respective alloantibody in the Ecuadorian population. Methods: It was performed a simple random sampling in the donor population, being later tested tube agglutination by the presence or absence of the antigen and its alloantibody Dia applying gel agglutination technique. Results: It was observed an antigen prevalence of 25% against a 6.09% of percentage alloimmunization due to Dia antigen, without significant differences between men and women and these being independent of the age and origin of the donor, showing that there are some Diego positive cases in Ecuadorian population as probably cases of transfusional alloinmunization or due to fetal-maternal alloinmunization. Conclusions and Recommendations: The frequency distribution of antigens and alloantibodies from the Diego blood group is almost uniform in the population, due presumably to the high incidence of miscegenation in our country. Therefore it becomes vitally important the implementation of this blood system inside the protocols of irregular antibodies identification in Ecuadorian blood banks. Copyright:
Authors: Adna Dos Santos Caldas; Bruno Costa Dos Santos; Maurício Koury Palmeira; Fabiana Regina Ribeiro Carvalho; Carlos Eduardo de Melo Amaral Journal: Hematol Transfus Cell Ther Date: 2021-02-11