Literature DB >> 2942012

Pharmacological activities of two new histamine analogs.

M Impicciatore, G Morini, M Chiavarini, P V Plazzi, F Bordi, F Vitali.   

Abstract

The pharmacological properties of 2-aminohistamine and 2-amino-5-methylhistamine were studied and compared with those of histamine, 5-methylhistamine and dimaprit. The introduction of an amino group in position 2 of the histamine imidazole ring caused a reduction of histamine potency, mostly with respect to H1 receptors. Such disactivation was much more evident in its corresponding 5-methyl derivative. The pharmacological activity related to the chemical structure will be discussed in the paper.

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Year:  1986        PMID： 2942012     DOI： 10.1007/bf01988003

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  7 in total

1.  Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

Authors:  J M VAN ROSSUM
Journal:  Arch Int Pharmacodyn Ther       Date:  1963

2.  Acid secretion by guinea-pig isolated stomach.

Authors:  P Holton; J Spencer
Journal:  J Physiol       Date:  1976-02       Impact factor: 5.182

3.  Definition and antagonism of histamine H 2 -receptors.

Authors:  J W Black; W A Duncan; C J Durant; C R Ganellin; E M Parsons
Journal:  Nature       Date:  1972-04-21       Impact factor: 49.962

4.  Synthesis of 2-amino-L-histidine and 2-aminohistamine.

Authors:  W Nagai; K L Kirk; L A Cohen
Journal:  J Org Chem       Date:  1973-06-01       Impact factor: 4.354

5.  [Imidazole H-2 agonists. Synthesis and activity of 2-(2-amino-4-imidazolyl)ethylamine (2-aminohistamine) dihydrochloride].

Authors:  T Vitali; M Impicciatore; P V Plazzi; F Bordi; M Vitto
Journal:  Farmaco Sci       Date:  1984-01

6.  Effects of alkyl analogs of histamine and metiamide on gastric acid secretion.

Authors:  M Impicciatore; M Chiavarini; R Razzetti; T Vitali
Journal:  Eur J Pharmacol       Date:  1979-07-15       Impact factor: 4.432

7.  [Imidazole H2-antagonists and H2-angonists: effects of 5-alkyl substitution].

Authors:  T Vitali; M Impicciatore; C Ferrari; G Morini
Journal:  Farmaco Sci       Date:  1980-05
  7 in total
  2 in total

1.  Pharmacological properties of the hydroxylated histamine, (+/-)-4(5)-(2-amino-1-hydroxyethyl)-imidazole.

Authors:  T Ishikawa; Y Kamisaki; T Itoh
Journal:  Agents Actions       Date:  1989-03

2.  Are histamine receptors involved in the stimulant activities of thiazolylethylamines supposed as cyclic models of dimaprit?

Authors:  M Impicciatore; G Morini; M Chiavarini; E Barocelli; F Bordi; P V Plazzi; F Vitali
Journal:  Agents Actions       Date:  1987-04
  2 in total

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