Literature DB >> 29420104

Tocilizumab as first treatment option in optic neuropathy secondary to Graves' orbitopathy.

I Pascual-Camps1, R Molina-Pallete1, M A Bort-Martí1, J Todolí2, E España-Gregori1,3.   

Abstract

Dysthyroid optic neuropathy (DON) is one of the complications that can affect Graves' orbitopathy (GO) patients. Its prevalence is estimated at less than 5%. It is usually treated with intravenous steroids, radiotherapy or orbital decompression. Tocilizumab has been proposed as a treatment option in cases of GO refractory to steroid treatment, with good clinical results. Our aim is to report the case of a patient with optic neuropathy secondary to GO treated with tocilizumab as primary treatment option.

Entities:  

Keywords:  Decompression; Graves’ orbitopathy; dysthyroid optic neuropathy; steroids; tocilizumab

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Substances:

Year:  2018        PMID: 29420104     DOI: 10.1080/01676830.2018.1435694

Source DB:  PubMed          Journal:  Orbit        ISSN: 0167-6830


  3 in total

Review 1.  Therapeutic difference between orbital decompression and glucocorticoids administration as the first-line treatment for dysthyroid optic neuropathy: a systematic review.

Authors:  Ming-Na Xu; Zhao-Qi Pan; Yun-Hai Tu; He-Qing Tao; Ke-Si Shi; Wen-Can Wu
Journal:  Int J Ophthalmol       Date:  2021-07-18       Impact factor: 1.779

2.  Thyroid Eye Disease: Navigating the New Treatment Landscape.

Authors:  Chrysoula Dosiou; Andrea Lora Kossler
Journal:  J Endocr Soc       Date:  2021-03-17

3.  The Therapeutic Effect of Combination of Orbital Decompression Surgery and Methylprednisolone Pulse Therapy on Patients with Bilateral Dysthyroid Optic Neuropathy.

Authors:  Jianan Xu; Huijing Ye; Guo Chen; Jingqiao Chen; Rongxin Chen; Huasheng Yang
Journal:  J Ophthalmol       Date:  2020-02-19       Impact factor: 1.909

  3 in total

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