Faiza Khalid1, Fernando Holguin2. 1. a Department of Internal Medicine , University Hospitals Cleveland Medical Center/ Case Western Reserve University , Cleveland , OH , USA. 2. b Division of Pulmonary and Critical Care , University of Colorado , Denver , CO , USA.
Abstract
OBJECTIVE: This literature review aims to compare obese-asthmatic adults and children, and to characterize differences and similarities between the two subgroups from epidemiological, demographical, phenotypical, and physiological perspectives. METHODS: Literature search was conducted using Pubmed database with "obesity," "asthma," "epidemiology," "cluster analysis," "demography," "mechanics," and ''FeNO'' as search terms. METHODS: Articles investigating epidemiological, demographic, phenotypical variation, and mechanical aspects of breathing specifically in obese asthmatics were identified. The studies were then divided according to age: children (<18 years of age) and adults (>18 years of age). RESULTS: Increase in asthma incidence and prevalence is observed in both obese-asthmatic children and adults. Asthma prevalence is greater in adult females regardless of ethnic background, and in men of African American and Hispanic ethnicities. Degree of weight gain and early onset of menarche appears to directly affect asthma severity in adolescent girls and females. Airway hyperresponsiveness and fractional exhaled nitric oxide do not have any positive correlation with high BMI in obese-asthmatic children and adults. Obesity also alters lung mechanics in asthmatics, but the impact is different for children and adults likely due to differential effect of obesity on central and peripheral airway. CONCLUSION: Existing literature suggests both similarities and differences in obese-asthmatic children and adults. The most pertinent differences are related to gender, ethnicity, and lung functions.
OBJECTIVE: This literature review aims to compare obese-asthmatic adults and children, and to characterize differences and similarities between the two subgroups from epidemiological, demographical, phenotypical, and physiological perspectives. METHODS: Literature search was conducted using Pubmed database with "obesity," "asthma," "epidemiology," "cluster analysis," "demography," "mechanics," and ''FeNO'' as search terms. METHODS: Articles investigating epidemiological, demographic, phenotypical variation, and mechanical aspects of breathing specifically in obese asthmatics were identified. The studies were then divided according to age: children (<18 years of age) and adults (>18 years of age). RESULTS: Increase in asthma incidence and prevalence is observed in both obese-asthmaticchildren and adults. Asthma prevalence is greater in adult females regardless of ethnic background, and in men of African American and Hispanic ethnicities. Degree of weight gain and early onset of menarche appears to directly affect asthma severity in adolescent girls and females. Airway hyperresponsiveness and fractional exhaled nitric oxide do not have any positive correlation with high BMI in obese-asthmaticchildren and adults. Obesity also alters lung mechanics in asthmatics, but the impact is different for children and adults likely due to differential effect of obesity on central and peripheral airway. CONCLUSION: Existing literature suggests both similarities and differences in obese-asthmaticchildren and adults. The most pertinent differences are related to gender, ethnicity, and lung functions.
Authors: Rafael E de la Hoz; Yunho Jeon; Anthony P Reeves; Raúl San José Estépar; Xiaoyu Liu; John T Doucette; Juan C Celedón; Anna Nolan Journal: Clin Respir J Date: 2019-08-19 Impact factor: 2.570
Authors: Traci A Bekelman; Dana Dabelea; Jody M Ganiban; Andrew Law; Alexandra McGovern Reilly; Keri N Althoff; Noel Mueller; Carlos A Camargo; Cristiane S Duarte; Anne L Dunlop; Amy J Elliott; Assiamira Ferrara; Diane R Gold; Irva Hertz-Picciotto; Tina Hartert; Alison E Hipwell; Kathi Huddleston; Christine C Johnson; Margaret R Karagas; Catherine J Karr; Gurjit K Khurana Hershey; Leslie Leve; Somdat Mahabir; Cindy T McEvoy; Jenae Neiderhiser; Emily Oken; Andrew Rundle; Sheela Sathyanarayana; Christine Turley; Frances A Tylavsky; Sara E Watson; Rosalind Wright; Mingyu Zhang; Edward Zoratti Journal: Obesity (Silver Spring) Date: 2021-08-31 Impact factor: 9.298