| Literature DB >> 29419319 |
Supojjanee Sansook1, Wei Tuo2, Mélanie Bollier2, Amélie Barczyk2, Xavier Dezitter2, Fredérique Klupsch2, Natascha Leleu-Chavain2, Amaury Farce2, Graham J Tizzard3, Simon J Coles3, John Spencer1, Régis Millet2.
Abstract
Ferrocene analogs of known fatty acid amide hydrolase inhibitors and CB2 ligands have been synthesized and characterized spectroscopically and crystallographically. The resulting bio-organometallic isoxazoles were assayed for their effects on CB1 and CB2 receptors as well as on fatty acid amide hydrolase. None had any fatty acid amide hydrolase activity but compound 3, 5-(2-(pentyloxy)phenyl)-N-ferrocenylisoxazole-3-carboxamide, was found to be a potent CB2 ligand (Ki = 32.5 nM).Entities:
Keywords: FAAH; cannabinoids; ferrocene; isoxazole
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Year: 2018 PMID： 29419319 DOI： 10.4155/fmc-2017-0200
Source DB: PubMed Journal: Future Med Chem ISSN： 1756-8919 Impact factor: 3.808