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Literature DB >> 2941815

Down's syndrome and Alzheimer's disease: a review.

Abstract

Neuropathological change found in nearly all individuals with Down's Syndrome over the age of 35 years closely resembles that of Alzheimer's disease. The extent to which dementia occurs as a result of this change is unclear, and the studies which have investigated presumed cognitive deficits are reviewed. The theories put forward to explain the association between these two disorders and their possible significance to the understanding of the aetiology of Alzheimer's disease are discussed.

Entities: Disease

Mesh：

Year: 1986 PMID： 2941815 DOI： 10.1017/s0033291700009120

Source DB: PubMed Journal: Psychol Med ISSN： 0033-2917 Impact factor: 7.723

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Cited

40 in total

1. The Link between Alzheimer's Disease and Down Syndrome. A Historical Perspective.

Authors: Ahmad Salehi; J Wesson Ashford; Elliott J Mufson
Journal: Curr Alzheimer Res Date: 2016 Impact factor: 3.498

2. Straight and paired helical filaments in Alzheimer disease have a common structural unit.

Authors: R A Crowther
Journal: Proc Natl Acad Sci U S A Date: 1991-03-15 Impact factor: 11.205

Review 3. Grief and its complications in individuals with intellectual disability.

Authors: Claire Brickell; Kerim Munir
Journal: Harv Rev Psychiatry Date: 2008 Impact factor: 3.732

4. Protocols to establish genotype-phenotype correlations in Down syndrome.

Authors: C J Epstein; J R Korenberg; G Annerén; S E Antonarakis; S Aymé; E Courchesne; L B Epstein; A Fowler; Y Groner; J L Huret
Journal: Am J Hum Genet Date: 1991-07 Impact factor: 11.025

5. Neuroimaging of individuals with Down's syndrome at-risk for dementia: evidence for possible compensatory events.

Authors: R J Haier; K Head; E Head; I T Lott
Journal: Neuroimage Date: 2007-10-12 Impact factor: 6.556

Review 6. Human adult stem cells as the target cells for the initiation of carcinogenesis and for the generation of "cancer stem cells".

Authors: James E Trosko
Journal: Int J Stem Cells Date: 2008-11 Impact factor: 2.500

Down's syndrome and Alzheimer's disease: a review.

1. The Link between Alzheimer's Disease and Down Syndrome. A Historical Perspective.

2. Straight and paired helical filaments in Alzheimer disease have a common structural unit.

Review 3. Grief and its complications in individuals with intellectual disability.

4. Protocols to establish genotype-phenotype correlations in Down syndrome.

5. Neuroimaging of individuals with Down's syndrome at-risk for dementia: evidence for possible compensatory events.

Review 6. Human adult stem cells as the target cells for the initiation of carcinogenesis and for the generation of "cancer stem cells".

7. Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease.

Review 8. The vexing complexity of the amyloidogenic pathway.

Review 9. Recent research on the causes of Alzheimer's disease.

10. Argyrophilic plaque-like deposits in children.