Literature DB >> 2941761

Antigen presentation by a B-cell line transfected with cloned immunoglobulin heavy- and light-chain genes specific for a defined hapten.

M Watanabe, D R Wegmann, A Ochi, N Hozumi.   

Abstract

The rearranged genes encoding immunoglobulin heavy (mu) and light (kappa) chains specific for the hapten 2,4,6-trinitrophenyl (Tnp) were introduced into a B-lymphoma line that bears surface IgG with an unknown specificity and expresses surface Ia molecules. A transformant expressing surface IgM specific for Tnp was obtained. The transformant was found to present Tnp-proteins to antigen (protein)-specific T cells far more efficiently than the parenteral B-lymphoma line. This artificial system, utilizing recombinant DNA technology and gene transfer, provides several approaches for the study of T-cell-B-cell interactions.

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Year:  1986        PMID： 2941761      PMCID： PMC323928          DOI： 10.1073/pnas.83.14.5247

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

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Authors:  R W Chesnut; H M Grey
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3.  Functional significance of the regulation of macrophage Ia expression.

Authors:  D I Beller
Journal:  Eur J Immunol       Date:  1984-02       Impact factor: 5.532

4.  Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.

Authors:  K Ozato; D H Sachs
Journal:  J Immunol       Date:  1981-01       Impact factor: 5.422

5.  Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

Authors:  K Ozato; N Mayer; D H Sachs
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6.  Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control.

Authors:  G H Sunshine; D R Katz; M Feldmann
Journal:  J Exp Med       Date:  1980-12-01       Impact factor: 14.307

7.  Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes.

Authors:  A S Rosenthal; E M Shevach
Journal:  J Exp Med       Date:  1973-11-01       Impact factor: 14.307

8.  The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.

Authors:  P Erb; M Feldmann
Journal:  J Exp Med       Date:  1975-08-01       Impact factor: 14.307

9.  Concanavalin A-inducible, interleukin-2-producing T cell hybridoma.

Authors:  L Harwell; B Skidmore; P Marrack; J Kappler
Journal:  J Exp Med       Date:  1980-10-01       Impact factor: 14.307

10.  Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition.

Authors:  J W Kappler; B Skidmore; J White; P Marrack
Journal:  J Exp Med       Date:  1981-05-01       Impact factor: 14.307
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  12 in total

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Authors:  Adam H Courtney; Erik B Puffer; Jason K Pontrello; Zhi-Qiang Yang; Laura L Kiessling
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Review 2.  Virus entry and antigen biosynthesis in the processing and presentation of class-II MHC-restricted T-cell determinants of influenza virus.

Authors:  C J Hackett; L C Eisenlohr
Journal:  Immunol Res       Date:  1990       Impact factor: 2.829

3.  Enhancement of antigen-presenting ability of B lymphoma cells by partial inhibition of protein synthesis through inducing B7-1 expression.

Authors:  T Aoi; H Nakano; Y Tanaka; T Kakiuchi
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4.  Assessment of antigen-specific receptor function of surface immunoglobulin M and D with identical hapten specificity.

Authors:  R Tisch; M Watanabe; M Letarte; N Hozumi
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

5.  Multivalent Antigens for Promoting B and T Cell Activation.

Authors:  Nitasha R Bennett; Daniel B Zwick; Adam H Courtney; Laura L Kiessling
Journal:  ACS Chem Biol       Date:  2015-06-02       Impact factor: 5.100

Review 6.  Warner-Lambert/Parke-Davis award lecture. Cellular interactions in the immune response. The roles of B lymphocytes and interleukin-4.

Authors:  A K Abbas
Journal:  Am J Pathol       Date:  1987-10       Impact factor: 4.307

7.  Interaction between T cell receptor beta chain and immunoglobulin heavy chain region genes in susceptibility to insulin-dependent diabetes mellitus.

Authors:  L L Field; D K Stephure; R G McArthur
Journal:  Am J Hum Genet       Date:  1991-09       Impact factor: 11.025

8.  Irradiation up-regulates CD80 expression through induction of tumour necrosis factor-alpha and CD40 ligand expression on B lymphoma cells.

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Journal:  Immunology       Date:  2002-07       Impact factor: 7.397

9.  Irradiation up-regulates CD80 expression through two different mechanisms in spleen B cells, B lymphoma cells, and dendritic cells.

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10.  Synthetic antigens reveal dynamics of BCR endocytosis during inhibitory signaling.

Authors:  Adam H Courtney; Nitasha R Bennett; Daniel B Zwick; Jonathan Hudon; Laura L Kiessling
Journal:  ACS Chem Biol       Date:  2013-11-14       Impact factor: 5.100
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