Enrico Giordan1, Waleed Brinjikji1,2, Roanna L Vine2, Giuseppe Lanzino3,4. 1. Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA. 2. Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. 3. Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA. Lanzino.giuspeppe@mayo.edu. 4. Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Lanzino.giuspeppe@mayo.edu.
Abstract
BACKGROUND AND PURPOSE: The rate of de novo aneurysm formation in patients with unruptured aneurysm without history of subarachnoid hemorrhage is scarcely defined in literature. We report the incidence of de novo aneurysm formation in a large contemporary series of patients with unruptured intracranial aneurysm (UIA) undergoing serial neurovascular imaging. METHODS: Neurovascular imaging studies of 321 consecutive UIA patients with no prior history of subarachnoid hemorrhage, with at least 3 years of follow-up imaging, were reviewed by a neuroradiologist and a neurosurgeon. Rate of de novo aneurysm formation was reported on a per-patient and per-patient-year basis. RESULTS: Of the 321 included patients, three patients (0.9%) developed a de novo aneurysm over a mean follow-up period of 5.2 years, for an incidence rate of 0.18% per patient-year. No de novo aneurysms ruptured and all three were 2 mm in size. CONCLUSIONS: The rate of de novo aneurysm formation in patients with unruptured aneurysms and no history of subarachnoid hemorrhage is very low. These data are useful to advice patients with unruptured aneurysms from another aneurysm and to plan imaging follow-ups in these patients.
BACKGROUND AND PURPOSE: The rate of de novo aneurysm formation in patients with unruptured aneurysm without history of subarachnoid hemorrhage is scarcely defined in literature. We report the incidence of de novo aneurysm formation in a large contemporary series of patients with unruptured intracranial aneurysm (UIA) undergoing serial neurovascular imaging. METHODS: Neurovascular imaging studies of 321 consecutive UIA patients with no prior history of subarachnoid hemorrhage, with at least 3 years of follow-up imaging, were reviewed by a neuroradiologist and a neurosurgeon. Rate of de novo aneurysm formation was reported on a per-patient and per-patient-year basis. RESULTS: Of the 321 included patients, three patients (0.9%) developed a de novo aneurysm over a mean follow-up period of 5.2 years, for an incidence rate of 0.18% per patient-year. No de novo aneurysms ruptured and all three were 2 mm in size. CONCLUSIONS: The rate of de novo aneurysm formation in patients with unruptured aneurysms and no history of subarachnoid hemorrhage is very low. These data are useful to advice patients with unruptured aneurysms from another aneurysm and to plan imaging follow-ups in these patients.
Entities:
Keywords:
De novo aneurysms; De novo formation; New aneurysms; Unruptured aneurysms
Authors: Irina M Sanchis; Shehbaz Shukoor; Maria V Irazabal; Charles D Madsen; Fouad T Chebib; Marie C Hogan; Ziad El-Zoghby; Peter C Harris; John Huston; Robert D Brown; Vicente E Torres Journal: Clin J Am Soc Nephrol Date: 2019-07-30 Impact factor: 8.237