| Literature DB >> 2941632 |
R L Webb, R Della Puca, J Manniello, R D Robson, M B Zimmerman, R D Ghai.
Abstract
Atrial natriuretic factor (ANF) increases sodium (Na+) and water excretion 8-10 fold on repeated administration to anesthetized rats. SCH-23390 (80 micrograms/kg i.v.) and R-sulpiride (80 micrograms/kg i.v.), selective antagonists of dopamine receptors in the renal vasculature, inhibited diuresis and natriuresis induced by AP III and dopamine. These findings suggest that ANF exerts its effects on renal Na+ and water handling via a dopaminergic mechanism; however, changes in intrarenal hemodynamics secondary to dopamine receptor blockade may attenuate the actions of ANF.Entities:
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Year: 1986 PMID： 2941632 DOI： 10.1016/0024-3205(86)90639-9
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037