| Literature DB >> 29416122 |
Li Liu1,2, Ruixing Liu1,2, Buddha Bahadur Basnet1,3, Li Bao1,2, Junjie Han1,2, Long Wang4, Hongwei Liu5,6.
Abstract
Three new bisabolane sesquiterpenoid esters, aspertenols A-B (1-3), and six known compounds (4-9) were isolated from the fungus Aspergillus tennesseensis. The structures of new compounds were elucidated by extensive spectroscopic analysis. The cytotoxicities of 1-9 against A549, K562, and ASPC cell lines were tested by using the CCK8 method. Compounds 1, 3, 4, 6, 7, and 9 showed inhibition on K562 cell line with IC50 values in the range from 16.6 to 72.7 μM. Compounds 1, 4, and 9 showed moderate inhibitory activity against A549 with IC50 of 43.5, 70.2, and 61.1 μM, respectively.Entities:
Mesh：
Substances：
Year: 2018 PMID： 29416122 DOI： 10.1038/s41429-018-0025-3
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649