Literature DB >> 29414591

Karyopherins in cancer.

Tolga Çağatay1, Yuh Min Chook2.   

Abstract

Malfunction of nuclear-cytoplasmic transport contributes to many diseases including cancer. Defective nuclear transport leads to changes in both the physiological levels and temporal-spatial location of tumor suppressors, proto-oncogenes and other macromolecules that in turn affect the tumorigenesis process and drug sensitivity of cancer cells. In addition to their nuclear transport functions in interphase, Karyopherin nuclear transport receptors also have important roles in mitosis and chromosomal integrity. Therefore, alterations in the expressions or regular functions of Karyopherins may have substantial effects on the course and outcome of diseases.
Copyright © 2018 Elsevier Ltd. All rights reserved.

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Year:  2018        PMID： 29414591      PMCID： PMC5988925          DOI： 10.1016/j.ceb.2018.01.006

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


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