J Rosner1, M Hubli2, P Hostettler1, P S Scheuren3, J Rinert1, J L K Kramer4, M Hupp1, A Curt1, C R Jutzeler5. 1. Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland. 2. Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland. Electronic address: Michele.Hubli@balgrist.ch. 3. International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada. 4. International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada; School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada. 5. Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada.
Abstract
OBJECTIVE: To investigate test-retest reliability of contact heat evoked potentials (CHEPs) from lower extremities using two different stimulation protocols, i.e., normal and increased baseline temperature. METHODS: A total of 32 able-bodied subjects were included and a subset (N = 22) was retested. CHEPs were recorded from three different dermatomes of the lower extremity (i.e., L2, L5, and S2). Test-retest reliability of CHEPs acquisition after simulation in various lower limb dermatomes using different stimulation protocols was analyzed. RESULTS: The study revealed an improved acquisition of CHEPS employing the increased baseline protocol, particularly when stimulating more distal sites, i.e., dermatome L5 and S2. Based on repeatability coefficients, CHEP latency (N2 potential) emerged as the most robust CHEP parameter. Although CHEP amplitudes (N2P2 complex) and pain ratings were decreased in the retest, amplitudes still showed fair to excellent intraclass correlation coefficients using normal baseline or increased baseline temperature, respectively. CONCLUSIONS: This is the first study to demonstrate that CHEPs acquisition from the lower extremities is improved by increasing the baseline temperature of the thermode. SIGNIFICANCE: This study highlights the usability of CHEPs as a viable diagnostic method to study small fiber integrity.
OBJECTIVE: To investigate test-retest reliability of contact heat evoked potentials (CHEPs) from lower extremities using two different stimulation protocols, i.e., normal and increased baseline temperature. METHODS: A total of 32 able-bodied subjects were included and a subset (N = 22) was retested. CHEPs were recorded from three different dermatomes of the lower extremity (i.e., L2, L5, and S2). Test-retest reliability of CHEPs acquisition after simulation in various lower limb dermatomes using different stimulation protocols was analyzed. RESULTS: The study revealed an improved acquisition of CHEPS employing the increased baseline protocol, particularly when stimulating more distal sites, i.e., dermatome L5 and S2. Based on repeatability coefficients, CHEP latency (N2 potential) emerged as the most robust CHEP parameter. Although CHEP amplitudes (N2P2 complex) and pain ratings were decreased in the retest, amplitudes still showed fair to excellent intraclass correlation coefficients using normal baseline or increased baseline temperature, respectively. CONCLUSIONS: This is the first study to demonstrate that CHEPs acquisition from the lower extremities is improved by increasing the baseline temperature of the thermode. SIGNIFICANCE: This study highlights the usability of CHEPs as a viable diagnostic method to study small fiber integrity.
Authors: Michèle Hubli; John L K Kramer; Catherine R Jutzeler; Jan Rosner; Julio C Furlan; Keith E Tansey; Martin Schubert Journal: Spinal Cord Date: 2019-07-23 Impact factor: 2.772
Authors: Iara De Schoenmacker; Carson Berry; Jean-Sébastien Blouin; Jan Rosner; Michèle Hubli; Catherine R Jutzeler; John L K Kramer Journal: Sci Rep Date: 2021-03-25 Impact factor: 4.379
Authors: J Rosner; P Hostettler; P S Scheuren; L Sirucek; J Rinert; A Curt; J L K Kramer; C R Jutzeler; M Hubli Journal: Sci Rep Date: 2018-07-20 Impact factor: 4.379