Fatemeh Salehi1, Ibrahim Abdollahpour2, Saharnaz Nedjat3, Mohammad Ali Sahraian4, Amir-Hossein Memari5, Maryam Rahnama5, Mohammad Ali Mansournia6. 1. Cohort study Center, Shahrekord University of Medical Sciences, Iran. 2. Department of Epidemiology, School of Public Health, Arak University of Medical Sciences, Iran. 3. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Iran; Knowledge Utilization Research Center, Tehran University of Medical Science, Iran. 4. MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Iran. 5. Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Iran. 6. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Iran. Electronic address: mansournia_m@sina.tums.ac.ir.
Abstract
BACKGROUND: Increase of MS prevalence in females compared to males, especially in reproductive age, highlights the important role of reproductive factors in MS pathology. OBJECTIVES: We examined the association between females' reproductive age-related factors and MS risk. METHODS: A case-control study including 399 cases and 541 controls was carried out. The adjusted associations between MS risk and reproductive variables including age at menarche, oral contraceptive pills (OCPs) use history, OCP usage duration and age at first use, history of assisted reproductive technologies (ARTs) use, parity history, age at first childbirth and the number of parities, abortion and exclusive breast feeding > 2 months were assessed. RESULTS: We found protective relationships between MS and older age at menarche (OR = 0.90 {95% CI = 0.82-0.98}), ART use history (OR = 0.45 {95% CI = 0.21-0.99}), older maternal age at first childbirth (OR = 0.94{95% CI = 0.89 - 0.99}) and higher number of parities(OR = 0.61 {95% CI = 0.49 - 0.75), whereas using OCPs was associated with higher risk of developing MS (OR = 1.80 {95% CI = 1.35-2.41}). CONCLUSIONS: Links were noted between a number of reproductive factors and risk of MS.
BACKGROUND: Increase of MS prevalence in females compared to males, especially in reproductive age, highlights the important role of reproductive factors in MS pathology. OBJECTIVES: We examined the association between females' reproductive age-related factors and MS risk. METHODS: A case-control study including 399 cases and 541 controls was carried out. The adjusted associations between MS risk and reproductive variables including age at menarche, oral contraceptive pills (OCPs) use history, OCP usage duration and age at first use, history of assisted reproductive technologies (ARTs) use, parity history, age at first childbirth and the number of parities, abortion and exclusive breast feeding > 2 months were assessed. RESULTS: We found protective relationships between MS and older age at menarche (OR = 0.90 {95% CI = 0.82-0.98}), ART use history (OR = 0.45 {95% CI = 0.21-0.99}), older maternal age at first childbirth (OR = 0.94{95% CI = 0.89 - 0.99}) and higher number of parities(OR = 0.61 {95% CI = 0.49 - 0.75), whereas using OCPs was associated with higher risk of developing MS (OR = 1.80 {95% CI = 1.35-2.41}). CONCLUSIONS: Links were noted between a number of reproductive factors and risk of MS.
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