Jing Zeng1, Yalin Xu2, Yao Shi3, Chenyin Jiang4. 1. Department of Neurology, Zhongshan Traditional Chinese Medicine Hospital, Zhongshan, 528400, China. Electronic address: jtnfft@163.com. 2. Department of Rehabilitation, Department of Rehabilitation Second people's Hospital of Jiangmen, Jiangmen, Guangdong 529030, China. Electronic address: yalinxu1@hotmail.com. 3. Rehabilitation Specialty, Jinan University, Guangzhou, 510632, China. Electronic address: oykswi@163.com. 4. Rehabilitation Specialty, Jinan University, Guangzhou, 510632, China. Electronic address: vtlrtv@163.com.
Abstract
OBJECTIVES: Prediabetes involves people with glucose-metabolism impairment, and is related to different diabetic complications, like peripheral neuropathy. We aimed to explore the relationship among inflammatory (tumor necrosis factor alpha [TNFα]) and antiinflammatory (interleukin 10 [IL10]) cytokines as well as neuropathy of very distal-sensory-nerves in Chinese patients with prediabetes/diabetes. PATIENTS AND METHODS: In the present study, 55 patients having prediabetes, 55 patients having type 2 diabetes mellitus (DM), and 48 controls were included. TNFα, HbA1c, and IL10 plasma levels were measured. Electrodiagnosis was conducted on dorsal-sural/medial-plantar sensory nerve, that is most distal feet sensory-nerves. RESULTS: Nerve conduction test (NCT) irregularities of dorsal-sural/medial-plantar sensory nerve were considerably greater in patients with prediabetes or diabetes. The means of TNFα levels demonstrated a significant increase in patients with diabetes when compared to prediabetes patients as well as controls showed a significant decrease in patients with prediabetes and diabetes contrasted with controls. No significant contrast with respect to serum biomarkers among patients having regular as well as irregular medial-plantar/dorsal-sural NCT was noted. Critical correlationship among TNFα as well as HbA1c with symptoms severity as well as disability while negative correlations of IL10 with neuropathy severity was noted. Biomarker levels of TNFα, IL10, and HbA1c were noted to differ significantly among patients without/with neuropathy. CONCLUSION: All in all, the proinflammatory phase appears to start from initial pre-clinical phases, sometime prior to advancement of diabetes. The higher neuropathy frequency in patients with prediabetes indicates conceivable causative impact; although, the prospective part of inflammation in pathogenetics of peripheral neuropathy requires more elucidation.
OBJECTIVES:Prediabetes involves people with glucose-metabolism impairment, and is related to different diabetic complications, like peripheral neuropathy. We aimed to explore the relationship among inflammatory (tumor necrosis factor alpha [TNFα]) and antiinflammatory (interleukin 10 [IL10]) cytokines as well as neuropathy of very distal-sensory-nerves in Chinese patients with prediabetes/diabetes. PATIENTS AND METHODS: In the present study, 55 patients having prediabetes, 55 patients having type 2 diabetes mellitus (DM), and 48 controls were included. TNFα, HbA1c, and IL10 plasma levels were measured. Electrodiagnosis was conducted on dorsal-sural/medial-plantar sensory nerve, that is most distal feet sensory-nerves. RESULTS: Nerve conduction test (NCT) irregularities of dorsal-sural/medial-plantar sensory nerve were considerably greater in patients with prediabetes or diabetes. The means of TNFα levels demonstrated a significant increase in patients with diabetes when compared to prediabetespatients as well as controls showed a significant decrease in patients with prediabetes and diabetes contrasted with controls. No significant contrast with respect to serum biomarkers among patients having regular as well as irregular medial-plantar/dorsal-sural NCT was noted. Critical correlationship among TNFα as well as HbA1c with symptoms severity as well as disability while negative correlations of IL10 with neuropathy severity was noted. Biomarker levels of TNFα, IL10, and HbA1c were noted to differ significantly among patients without/with neuropathy. CONCLUSION: All in all, the proinflammatory phase appears to start from initial pre-clinical phases, sometime prior to advancement of diabetes. The higher neuropathy frequency in patients with prediabetes indicates conceivable causative impact; although, the prospective part of inflammation in pathogenetics of peripheral neuropathy requires more elucidation.
Authors: Varo Kirthi; Anugraha Perumbalath; Emily Brown; Sarah Nevitt; Ioannis N Petropoulos; Jamie Burgess; Rebecca Roylance; Daniel J Cuthbertson; Timothy L Jackson; Rayaz A Malik; Uazman Alam Journal: BMJ Open Diabetes Res Care Date: 2021-05
Authors: Mahmoud A Allam; Youssef A Nassar; Hosameldeen S Shabana; Sadek Mostafa; Farag Khalil; Hendawy Zidan; Mohammed Abo-Ghebsha; Amir Abdelghaffar; Ahmed Essmat; Essam Elmahdi Journal: Int J Gen Med Date: 2021-11-06