Sandy Figiel1, Michelle Pinault1, Isabelle Domingo1, Cyrille Guimaraes1, Roseline Guibon2, Pierre Besson1, Elsa Tavernier3, Pascal Blanchet4, Luc Multigner5, Franck Bruyère6, Olivier Haillot6, Romain Mathieu7, Sebastien Vincendeau7, Nathalie Rioux-Leclercq7, Souhil Lebdai8, Abdel-Rahmene Azzouzi8, Marie-Aimee Perrouin-Verbe9, Georges Fournier9, Laurent Doucet9, Jerome Rigaud10, Karine Renaudin10, Karine Mahéo1, Gaëlle Fromont11. 1. Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 Bd Tonnellé, 37032 Tours, France. 2. Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 Bd Tonnellé, 37032 Tours, France; CHRU Bretonneau, Department of Pathology, Tours, France; CHRU Bretonneau, Department of Urology, Tours, France. 3. CHRU Tours, Clinical Investigation Center - INSERM 1415, Tours, France. 4. CHU Pointe à Pitre, Department of Urology, Guadeloupe, France; Inserm UMR1085 - IRSET, Rennes, France. 5. Inserm UMR1085 - IRSET, Rennes, France. 6. CHRU Bretonneau, Department of Pathology, Tours, France; CHRU Bretonneau, Department of Urology, Tours, France. 7. CHU Rennes, Department of Pathology, Rennes, France; CHU Rennes, Department of Urology, Rennes, France. 8. CHU Angers, Department of Urology, Angers, France. 9. CHU Brest, Department of Pathology, Brest, France; CHU Brest, Department of Urology, Brest, France. 10. CHU Nantes, Department of Pathology, Nantes, France; CHU Nantes, Department of Urology, Nantes, France. 11. Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 Bd Tonnellé, 37032 Tours, France; CHRU Bretonneau, Department of Pathology, Tours, France; CHRU Bretonneau, Department of Urology, Tours, France. Electronic address: gaelle.fromont-hankard@univ-tours.fr.
Abstract
BACKGROUND: Genetic and nutritional factors have been linked to the risk of aggressive prostate cancer (PCa). The fatty acid (FA) composition of peri-prostatic adipose tissue (PPAT), which reflects the past FA intake, is potentially involved in PCa progression. We analysed the FA composition of PPAT, in correlation with the ethno-geographical origin of the patients and markers of tumour aggressiveness. METHODS: From a cohort of 1000 men treated for PCa by radical prostatectomy, FA composition of PPAT was analysed in 156 patients (106 Caucasians and 50 African-Caribbeans), 78 with an indolent tumour (ISUP group 1 + pT2 + PSA <10 ng/mL) and 78 with an aggressive tumour (ISUP group 4-5 + pT3). The effect of FA extracted from PPAT on in-vitro migration of PCa cells DU145 was studied in 72 patients, 36 Caucasians, and 36 African-Caribbeans. RESULTS: FA composition differed according to the ethno-geographical origin. Linoleic acid, an essential n-6 FA, was 2-fold higher in African-Caribbeans compared with Caucasian patients, regardless of disease aggressiveness. In African-Caribbeans, the FA profile associated with PCa aggressiveness was characterised by low level of linoleic acid along with high levels of saturates. In Caucasians, a weak and negative association was observed between eicosapentaenoic acid level (an n-3 FA) and disease aggressiveness. In-vitro migration of PCa cells using PPAT from African-Caribbean patients was associated with lower content of linoleic acid. CONCLUSION: These results highlight an important ethno-geographical variation of PPAT, in both their FA content and association with tumour aggressiveness.
BACKGROUND: Genetic and nutritional factors have been linked to the risk of aggressive prostate cancer (PCa). The fatty acid (FA) composition of peri-prostatic adipose tissue (PPAT), which reflects the past FA intake, is potentially involved in PCa progression. We analysed the FA composition of PPAT, in correlation with the ethno-geographical origin of the patients and markers of tumour aggressiveness. METHODS: From a cohort of 1000 men treated for PCa by radical prostatectomy, FA composition of PPAT was analysed in 156 patients (106 Caucasians and 50 African-Caribbeans), 78 with an indolent tumour (ISUP group 1 + pT2 + PSA <10 ng/mL) and 78 with an aggressive tumour (ISUP group 4-5 + pT3). The effect of FA extracted from PPAT on in-vitro migration of PCa cells DU145 was studied in 72 patients, 36 Caucasians, and 36 African-Caribbeans. RESULTS: FA composition differed according to the ethno-geographical origin. Linoleic acid, an essential n-6 FA, was 2-fold higher in African-Caribbeans compared with Caucasian patients, regardless of disease aggressiveness. In African-Caribbeans, the FA profile associated with PCa aggressiveness was characterised by low level of linoleic acid along with high levels of saturates. In Caucasians, a weak and negative association was observed between eicosapentaenoic acid level (an n-3 FA) and disease aggressiveness. In-vitro migration of PCa cells using PPAT from African-Caribbean patients was associated with lower content of linoleic acid. CONCLUSION: These results highlight an important ethno-geographical variation of PPAT, in both their FA content and association with tumour aggressiveness.
Authors: Maria G Grammatikopoulou; Konstantinos Gkiouras; Stefanos Τ Papageorgiou; Ioannis Myrogiannis; Ioannis Mykoniatis; Theodora Papamitsou; Dimitrios P Bogdanos; Dimitrios G Goulis Journal: Nutrients Date: 2020-09-29 Impact factor: 5.717
Authors: Ibrahim AlZaim; Aya Al-Saidi; Safaa H Hammoud; Nadine Darwiche; Yusra Al-Dhaheri; Ali H Eid; Ahmed F El-Yazbi Journal: Cancers (Basel) Date: 2022-03-25 Impact factor: 6.639
Authors: Antonio Altuna-Coy; Xavier Ruiz-Plazas; José Segarra-Tomás; Matilde R Chacón; Silvia Sánchez-Martin; Helena Ascaso-Til; Manuel Prados-Saavedra; Marta Alves-Santiago; Xana Bernal-Escoté Journal: BMC Med Date: 2022-08-18 Impact factor: 11.150