Literature DB >> 29413883

The role of regulatory T cells in immunopathogenesis and immunotherapy of viral infections.

Ahmad Karkhah1, Mostafa Javanian2, Soheil Ebrahimpour3.   

Abstract

Two hepatotropic viruses hepatitis C virus (HCV) and hepatitis B virus (HBV) have been considered as the main cause of chronic viral infections. In addition, human immunodeficiency virus (HIV) attacks the immune system by eradication of some white blood cell (T-helper cell). The role of Tregs in HCV, HBV and HIV infections ranges from suppressing antiviral T cell responses to protecting tissues as liver and immune cells from immune mediated injury. In this review, we discuss the influence of regulatory T cells in immunopathology of specific viral infections including HCV, HBV and HIV by focusing on targeting Tregs as novel approach in vaccinology against viral infections.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Pathogenesis; Regulatory T cells; Viral infection

Mesh：

Substances：

Year:  2018        PMID： 29413883     DOI： 10.1016/j.meegid.2018.01.015

Source DB:  PubMed          Journal:  Infect Genet Evol        ISSN： 1567-1348            Impact factor:   3.342


  12 in total

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