Literature DB >> 29413423

Genomic Landscape of Pheochromocytoma and Paraganglioma.

Ivana Jochmanova1, Karel Pacak2.   

Abstract

Recent comprehensive molecular analysis allowed the identification of unique molecular signatures in pheochromocytomas (PHEOs) and paragangliomas (PGLs). Here we summarize the main pathway clusters activated by PHEO- and PGL-susceptibility genes: pseudohypoxic, kinase, and Wnt signaling. Molecular characterization and clustering of PHEOs and PGLs may help in the application of principles of personalized medicine and in decision making for targeted therapy of these tumors. Published by Elsevier Inc.

Entities:  

Keywords:  genetics; paraganglioma; pheochromocytoma; signaling pathways

Mesh：

Substances：

Year:  2017        PMID： 29413423      PMCID： PMC5819363          DOI： 10.1016/j.trecan.2017.11.001

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  11 in total

Review 1.  Review paper: origin and molecular pathology of adrenocortical neoplasms.

Authors:  M Bielinska; H Parviainen; S Kiiveri; M Heikinheimo; D B Wilson
Journal:  Vet Pathol       Date:  2009-03       Impact factor: 2.221

Review 2.  Pheochromocytoma: The First Metabolic Endocrine Cancer.

Authors:  Ivana Jochmanova; Karel Pacak
Journal:  Clin Cancer Res       Date:  2016-10-15       Impact factor: 12.531

Review 3.  A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells.

Authors:  Philippe Icard; Hubert Lincet
Journal:  Biochim Biophys Acta       Date:  2012-07-25

4.  Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma.

Authors:  Graeme Eisenhofer; Jacques W M Lenders; Henri Timmers; Massimo Mannelli; Stefan K Grebe; Lorenz C Hofbauer; Stefan R Bornstein; Oliver Tiebel; Karen Adams; Gennady Bratslavsky; W Marston Linehan; Karel Pacak
Journal:  Clin Chem       Date:  2011-01-24       Impact factor: 8.327

5.  Genotype-specific differences in the tumor metabolite profile of pheochromocytoma and paraganglioma using untargeted and targeted metabolomics.

Authors:  J U Rao; U F H Engelke; F C G J Sweep; K Pacak; B Kusters; A G Goudswaard; A R M M Hermus; A R Mensenkamp; G Eisenhofer; N Qin; S Richter; H P M Kunst; H J L M Timmers; R A Wevers
Journal:  J Clin Endocrinol Metab       Date:  2014-12-02       Impact factor: 5.958

Review 6.  Paraganglioma and phaeochromocytoma: from genetics to personalized medicine.

Authors:  Judith Favier; Laurence Amar; Anne-Paule Gimenez-Roqueplo
Journal:  Nat Rev Endocrinol       Date:  2014-11-11       Impact factor: 43.330

7.  Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma.

Authors:  Lauren Fishbein; Ignaty Leshchiner; Vonn Walter; Ludmila Danilova; A Gordon Robertson; Amy R Johnson; Tara M Lichtenberg; Bradley A Murray; Hans K Ghayee; Tobias Else; Shiyun Ling; Stuart R Jefferys; Aguirre A de Cubas; Brandon Wenz; Esther Korpershoek; Antonio L Amelio; Liza Makowski; W Kimryn Rathmell; Anne-Paule Gimenez-Roqueplo; Thomas J Giordano; Sylvia L Asa; Arthur S Tischler; Karel Pacak; Katherine L Nathanson; Matthew D Wilkerson
Journal:  Cancer Cell       Date:  2017-02-02       Impact factor: 31.743

Review 8.  An update on the genetics of paraganglioma, pheochromocytoma, and associated hereditary syndromes.

Authors:  A-P Gimenez-Roqueplo; P L Dahia; M Robledo
Journal:  Horm Metab Res       Date:  2012-02-10       Impact factor: 2.936

9.  ATRX driver mutation in a composite malignant pheochromocytoma.

Authors:  Iñaki Comino-Méndez; Águeda M Tejera; María Currás-Freixes; Laura Remacha; Pablo Gonzalvo; Raúl Tonda; Rocío Letón; María A Blasco; Mercedes Robledo; Alberto Cascón
Journal:  Cancer Genet       Date:  2016-04-26

10.  Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas.

Authors:  Rodrigo A Toledo; Yuejuan Qin; Zi-Ming Cheng; Qing Gao; Shintaro Iwata; Gustavo M Silva; Manju L Prasad; I Tolgay Ocal; Sarika Rao; Neil Aronin; Marta Barontini; Jan Bruder; Robert L Reddick; Yidong Chen; Ricardo C T Aguiar; Patricia L M Dahia
Journal:  Clin Cancer Res       Date:  2015-12-23       Impact factor: 12.531
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  30 in total

Review 1.  Metastatic Phaeochromocytoma: Spinning Towards More Promising Treatment Options.

Authors:  Svenja Nölting; Ashley Grossman; Karel Pacak
Journal:  Exp Clin Endocrinol Diabetes       Date:  2018-09-20       Impact factor: 2.949

Review 2.  Molecular imaging and radionuclide therapy of pheochromocytoma and paraganglioma in the era of genomic characterization of disease subgroups.

Authors:  David Taïeb; Abhishek Jha; Giorgio Treglia; Karel Pacak
Journal:  Endocr Relat Cancer       Date:  2019-11       Impact factor: 5.678

3.  Synergistic Highly Potent Targeted Drug Combinations in Different Pheochromocytoma Models Including Human Tumor Cultures.

Authors:  Maria Fankhauser; Nicole Bechmann; Michael Lauseker; Judith Goncalves; Judith Favier; Barbara Klink; Doreen William; Laura Gieldon; Julian Maurer; Gerald Spöttl; Petra Rank; Thomas Knösel; Michael Orth; Christian G Ziegler; Elke Tatjana Aristizabal Prada; German Rubinstein; Martin Fassnacht; Christine Spitzweg; Ashley B Grossman; Karel Pacak; Felix Beuschlein; Stefan R Bornstein; Graeme Eisenhofer; Christoph J Auernhammer; Martin Reincke; Svenja Nölting
Journal:  Endocrinology       Date:  2019-11-01       Impact factor: 4.736

Review 4.  Management of Pheochromocytomas and Paragangliomas: A Case-Based Review of Clinical Aspects and Perspectives.

Authors:  Bartosz Kamil Sobocki; Adrian Perdyan; Olga Szot; Jacek Rutkowski
Journal:  J Clin Med       Date:  2022-05-05       Impact factor: 4.964

Review 5.  Pheochromocytoma/paraganglioma: recent updates in genetics, biochemistry, immunohistochemistry, metabolomics, imaging and therapeutic options.

Authors:  Karren Antonio; Ma Margarita Noreen Valdez; Leilani Mercado-Asis; David Taïeb; Karel Pacak
Journal:  Gland Surg       Date:  2020-02

Review 6.  A Guide to Pheochromocytomas and Paragangliomas.

Authors:  Julie Guilmette; Peter M Sadow
Journal:  Surg Pathol Clin       Date:  2019-09-28

Review 7.  Pheochromocytoma and Paraganglioma: From Epidemiology to Clinical Findings.

Authors:  Nurcihan Aygun; Mehmet Uludag
Journal:  Sisli Etfal Hastan Tip Bul       Date:  2020-06-03

8.  A First Case Report of Orbital Extra-Adrenal Paraganglioma in Cat.

Authors:  Leonardo Leonardi; Raluca Ioana Rizac; Ilaria Pettinari; Luca Mechelli; Carlo De Feo
Journal:  Vet Sci       Date:  2021-05-14

9.  A Novel, Likely Pathogenic MAX Germline Variant in a Patient With Unilateral Pheochromocytoma.

Authors:  César Ernesto Lam-Chung; Larissa López Rodríguez; Jazmín Arteaga Vázquez; Yanin Chávarri-Guerra; Rebeca Arízaga-Ramírez; Orlando Falcon Antonio; Jazmín De Anda González; María Aurelia López-Hernández; Jeffrey N Weitzel; Danielle Castillo; Francisco Javier Gómez-Pérez; Daniel Cuevas-Ramos
Journal:  J Endocr Soc       Date:  2021-06-03

10.  A case report of rare ectopic pheochromocytoma adjacent to pancreas.

Authors:  Chenshan Jiang; Jianguo Zhao; Li Sun; Bing Cai
Journal:  Medicine (Baltimore)       Date:  2020-06-19       Impact factor: 1.817
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