Megan Kalambo1, Beatriz E Adrada1, Modupe M Adeyefa2, Savitri Krishnamurthy3, Ken Hess4, Selin Carkaci5, Gary J Whitman1. 1. 1 Department of Radiology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1350, Houston, TX 77030. 2. 2 Department of Breast Imaging, The Methodist Hospital, Houston, TX. 3. 3 Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX. 4. 4 Department of Statistics, The University of Texas M.D. Anderson Cancer Center, Houston, TX. 5. 5 Department of Radiology, The University of Miami Miller School of Medicine, Miami, FL.
Abstract
OBJECTIVE: The purpose of this study is to evaluate the sonographic and histopathologic features distinguishing benign from borderline and malignant phyllodes tumors. MATERIALS AND METHODS: The ultrasound examinations of women with pathologically proven phyllodes tumors from 2004 to 2011 were retrospectively reviewed. The sonographic features of benign, borderline, and malignant phyllodes tumors were compared and analyzed using the American College of Radiology's BI-RADS ultrasound lexicon. Fisher exact test and Wilcoxon rank sum test were used for statistical analysis. RESULTS: Fifty-nine women were included in the study; 28 benign (47%), 19 malignant (32%), and 12 borderline (20%) phyllodes tumors were identified. Significant univariate predictors of increased risk of borderline or malignant phyllodes tumors were patient age greater than 55 years (p = 0.014), irregular lesion shape (p = 0.011), and longest lesion dimension greater than 7 cm (p = 0.0022) at sonography. No significant differences were observed in lesion margins, boundaries, echo patterns, or posterior acoustic features. CONCLUSION: There is substantial overlap in the sonographic features of benign and borderline or malignant phyllodes tumors. Understanding the clinical and sonographic features of phyllodes tumors may aid the radiologist in predicting biological behavior, including the likelihood of benign versus borderline or malignant phyllodes tumors at pathologic analysis.
OBJECTIVE: The purpose of this study is to evaluate the sonographic and histopathologic features distinguishing benign from borderline and malignant phyllodes tumors. MATERIALS AND METHODS: The ultrasound examinations of women with pathologically proven phyllodestumors from 2004 to 2011 were retrospectively reviewed. The sonographic features of benign, borderline, and malignant phyllodes tumors were compared and analyzed using the American College of Radiology's BI-RADS ultrasound lexicon. Fisher exact test and Wilcoxon rank sum test were used for statistical analysis. RESULTS: Fifty-nine women were included in the study; 28 benign (47%), 19 malignant (32%), and 12 borderline (20%) phyllodestumors were identified. Significant univariate predictors of increased risk of borderline or malignant phyllodes tumors were patient age greater than 55 years (p = 0.014), irregular lesion shape (p = 0.011), and longest lesion dimension greater than 7 cm (p = 0.0022) at sonography. No significant differences were observed in lesion margins, boundaries, echo patterns, or posterior acoustic features. CONCLUSION: There is substantial overlap in the sonographic features of benign and borderline or malignant phyllodes tumors. Understanding the clinical and sonographic features of phyllodestumors may aid the radiologist in predicting biological behavior, including the likelihood of benign versus borderline or malignant phyllodes tumors at pathologic analysis.
Authors: Jessica Limberg; Kelly Barker; Syed Hoda; Rache Simmons; Aya Michaels; Jennifer L Marti Journal: World J Surg Date: 2020-05 Impact factor: 3.352
Authors: Mei Er Tu He Ta Mi Shi; Ning Wang; Qing Yao; Shuang-Shuang Dong; Xiao Feng; Jin Zhao; Hong Zou; Li-Juan Pang; Yan Qi Journal: Onco Targets Ther Date: 2021-05-06 Impact factor: 4.147
Authors: Ilaria Testa; Cristina Salvatori; Marco Prestipino; Maria Elena Laurenti; Paolo Gerli; Giuseppe Di Cara; Nicola Principi; Susanna Esposito; Mirko Bertozzi Journal: Int J Environ Res Public Health Date: 2018-05-11 Impact factor: 3.390