Jiabin Zheng1, Renjie Li1, Haibo Qiu2, Tao Chen3, Yongjian Zhou4, Changming Huang4, Guoxin Li3, Zhiwei Zhou2, Yong Li1. 1. Department of General Surgery, Guangdong General Hospital; Guangdong Academy of Medical Sciences, Guangzhou, PR China. 2. Department of Gastric & Pancreatic Surgery, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China. 3. Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, PR China. 4. Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, PR China.
Abstract
AIM: We aimed to investigate the optimal criteria for classifying higher risk forms of gastric gastrointestinal stromal tumor (gGIST). MATERIALS & METHODS: A total of 246 high-risk gGIST patients were enrolled. Univariate and multivariate analyses were conducted to determine the association between clinicopathological features and overall survival. Appropriate cut-off values were calculated to identify those at higher risk of gGIST. RESULTS: Multivariate and univariate analyses revealed that tumor necrosis and mitotic counts are independent risk factors for overall survival. The optimal cut-off value of mitotic counts was 20. Patients with both necrosis and >20 mitoses/50 high-power fields were worse than those with either one. CONCLUSION: Tumor necrosis and >20 mitoses/50 high-power fields are independent risk factors for high-risk gGIST. Patients with both risk factors indicate worse prognosis.
AIM: We aimed to investigate the optimal criteria for classifying higher risk forms of gastric gastrointestinal stromal tumor (gGIST). MATERIALS & METHODS: A total of 246 high-risk gGIST patients were enrolled. Univariate and multivariate analyses were conducted to determine the association between clinicopathological features and overall survival. Appropriate cut-off values were calculated to identify those at higher risk of gGIST. RESULTS: Multivariate and univariate analyses revealed that tumor necrosis and mitotic counts are independent risk factors for overall survival. The optimal cut-off value of mitotic counts was 20. Patients with both necrosis and >20 mitoses/50 high-power fields were worse than those with either one. CONCLUSION:Tumor necrosis and >20 mitoses/50 high-power fields are independent risk factors for high-risk gGIST. Patients with both risk factors indicate worse prognosis.