Literature DB >> 2941141

Clinical evaluation of schizophyllan combined with irradiation in patients with cervical cancer. A randomized controlled study.

K Okamura, M Suzuki, T Chihara, A Fujiwara, T Fukuda, S Goto, K Ichinohe, S Jimi, T Kasamatsu, N Kawai.   

Abstract

To evaluate the clinical effects of the anti-tumor polysaccharide Schizophyllan (SPG), a randomized study was done on 220 patients with Stage II or Stage III cervical cancer who had been given irradiation, concomitantly. The tumor-reducing effect of SPG was significant in patients in either stage. The time to recurrence was longer in SPG-dosed patients with Stage II cancer, compared with findings in the control group. There was no significant difference in the time to recurrence in patients with Stage III cancer between the SPG and control groups. When comparing the 48-month survival curve, the survival time of patients with Stage II cancer in the SPG group was significantly longer than in the control group. However, there was no significant difference in the survival rate of patients with Stage III cancer between the SPG-dosed and control groups.

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Year:  1986        PMID: 2941141     DOI: 10.1002/1097-0142(19860815)58:4<865::aid-cncr2820580411>3.0.co;2-s

Source DB:  PubMed          Journal:  Cancer        ISSN: 0008-543X            Impact factor:   6.860


  14 in total

1.  β-Glucan from Lentinus edodes inhibits nitric oxide and tumor necrosis factor-α production and phosphorylation of mitogen-activated protein kinases in lipopolysaccharide-stimulated murine RAW 264.7 macrophages.

Authors:  Xiaojuan Xu; Michiko Yasuda; Sachiko Nakamura-Tsuruta; Masashi Mizuno; Hitoshi Ashida
Journal:  J Biol Chem       Date:  2011-11-18       Impact factor: 5.157

2.  Immunomodulatory beta-glucan from Lentinus edodes activates mitogen-activated protein kinases and nuclear factor-kappaB in murine RAW 264.7 macrophages.

Authors:  Xiaojuan Xu; Chen Pan; Lina Zhang; Hitoshi Ashida
Journal:  J Biol Chem       Date:  2011-07-20       Impact factor: 5.157

Review 3.  Mushroom Polysaccharide-Assisted Anticarcinogenic Mycotherapy: Reviewing Its Clinical Trials.

Authors:  Iyyakkannu Sivanesan; Manikandan Muthu; Judy Gopal; Jae-Wook Oh
Journal:  Molecules       Date:  2022-06-25       Impact factor: 4.927

4.  Synthesis and Evaluation of 1,5-Dithia-d-laminaribiose, Triose, and Tetraose as Truncated β-(1→3)-Glucan Mimetics.

Authors:  Xiaoxiao Liao; Václav Větvička; David Crich
Journal:  J Org Chem       Date:  2018-12-04       Impact factor: 4.354

Review 5.  Biomedical issues of dietary fiber beta-glucan.

Authors:  Soo Young Kim; Hong Ji Song; Yoon Young Lee; Kyung-Hwan Cho; Yong Kyun Roh
Journal:  J Korean Med Sci       Date:  2006-10       Impact factor: 2.153

6.  Induction of gene expression for immunomodulating cytokines in peripheral blood mononuclear cells in response to orally administered PSK, an immunomodulating protein-bound polysaccharide.

Authors:  M Kato; K Hirose; M Hakozaki; M Ohno; Y Saito; R Izutani; J Noguchi; Y Hori; S Okumoto; D Kuroda
Journal:  Cancer Immunol Immunother       Date:  1995-03       Impact factor: 6.968

7.  Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist.

Authors:  Kouji Kobiyama; Taiki Aoshi; Hirotaka Narita; Etsushi Kuroda; Masayuki Hayashi; Kohhei Tetsutani; Shohei Koyama; Shinichi Mochizuki; Kazuo Sakurai; Yuko Katakai; Yasuhiro Yasutomi; Shinobu Saijo; Yoichiro Iwakura; Shizuo Akira; Cevayir Coban; Ken J Ishii
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-10       Impact factor: 11.205

8.  Activation of Macrophages by Exopolysaccharide Produced by MK1 Bacterial Strain Isolated from Neungee Mushroom, Sarcodon aspratus.

Authors:  Sun-A Im; Wenxia Wang; Chong-Kil Lee; Young Nam Lee
Journal:  Immune Netw       Date:  2010-12-31       Impact factor: 6.303

9.  Dendritic cell activation by glucan isolated from umbilicaria esculenta.

Authors:  Hyung Sook Kim; Jee Youn Kim; Hong Kyung Lee; Moo Sung Kim; Sang Rin Lee; Jong Soon Kang; Hwan Mook Kim; Kyung-Ae Lee; Jin Tae Hong; Youngsoo Kim; Sang-Bae Han
Journal:  Immune Netw       Date:  2010-12-31       Impact factor: 6.303

Review 10.  Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells.

Authors:  Xiukun Lin; Ammad Ahmad Farooqi; Muhammad Ismail
Journal:  Drug Des Devel Ther       Date:  2015-03-26       Impact factor: 4.162

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