Matthias C Reichert1, Marcin Krawczyk2,3, Beate Appenrodt2, Markus Casper2, Bettina Friesenhahn-Ochs2, Frank Grünhage2, Christoph Jüngst2, Vincent Zimmer2, Frank Lammert2, Marc Dauer2,4. 1. Department of Medicine II, Saarland University Medical Center, 66421, Homburg, Germany. matthias.reichert@uks.eu. 2. Department of Medicine II, Saarland University Medical Center, 66421, Homburg, Germany. 3. Laboratory of Metabolic Liver Diseases, Centre for Preclinical Research, Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland. 4. Department Medicine 2, Klinikum St. Marien, Amberg, Germany.
Abstract
PURPOSE: The purpose of this study is to investigate the association of intake of nonsteroidal anti-inflammatory drugs (NSAIDs) and in particular nonaspirin NSAIDs and compare it with other risk factors for the progression of diverticulosis to diverticulitis in patients who underwent colonoscopy. METHODS: A total of 194 patients who underwent complete colonoscopy in our center between 2012 and 2016 were recruited: 144 with diverticulosis without prior diverticulitis (median age 71 years, 59.7% men) and 50 with diverticulitis (median age 64 years, 54.0% men). Data concerning current and previous medication as well as concomitant diseases were collected using a structured questionnaire and by revision of patients medical charts. RESULTS: Patients with diverticulitis were significantly (p < 0.001) younger as compared to individuals with plain diverticulosis (median age 64 versus 71 years, respectively). The intake of NSAIDs significantly (p = 0.002) increased the risk of prior diverticulitis (OR 3.2, 95% CI 1.5-6.9). In the multivariate model, both age (p < 0.001) and NSAIDs (p = 0.03) proved to be independent determinants of diverticulitis. When analyzing aspirin intake, it was not associated with diverticulitis. CONCLUSIONS: Our study demonstrates, in line with previous reports, that intake of NSAIDs is associated with diverticulitis. We show in particular that nonaspirin NSAIDs might be selectively associated with diverticulitis. These results point to divergent role of aspirin and nonaspirin NSAIDs in the development of diverticulitis.
PURPOSE: The purpose of this study is to investigate the association of intake of nonsteroidal anti-inflammatory drugs (NSAIDs) and in particular nonaspirin NSAIDs and compare it with other risk factors for the progression of diverticulosis to diverticulitis in patients who underwent colonoscopy. METHODS: A total of 194 patients who underwent complete colonoscopy in our center between 2012 and 2016 were recruited: 144 with diverticulosis without prior diverticulitis (median age 71 years, 59.7% men) and 50 with diverticulitis (median age 64 years, 54.0% men). Data concerning current and previous medication as well as concomitant diseases were collected using a structured questionnaire and by revision of patients medical charts. RESULTS:Patients with diverticulitis were significantly (p < 0.001) younger as compared to individuals with plain diverticulosis (median age 64 versus 71 years, respectively). The intake of NSAIDs significantly (p = 0.002) increased the risk of prior diverticulitis (OR 3.2, 95% CI 1.5-6.9). In the multivariate model, both age (p < 0.001) and NSAIDs (p = 0.03) proved to be independent determinants of diverticulitis. When analyzing aspirin intake, it was not associated with diverticulitis. CONCLUSIONS: Our study demonstrates, in line with previous reports, that intake of NSAIDs is associated with diverticulitis. We show in particular that nonaspirin NSAIDs might be selectively associated with diverticulitis. These results point to divergent role of aspirin and nonaspirin NSAIDs in the development of diverticulitis.
Entities:
Keywords:
Aspirin; Diverticular disease; Diverticulitis; Diverticulosis; Nonsteroidal anti-inflammatory drug
Authors: Michael O'Grady; Louise Clarke; Gregory Turner; Matt Doogue; Rachel Purcell; John Pearson; Frank Frizelle Journal: Medicine (Baltimore) Date: 2020-05 Impact factor: 1.889
Authors: Wisam Sbeit; Tawfik Khoury; Anas Kadah; Waseem Asadi; Amir Shahin; Ahmad Lubany; Mohammed Safadi; Haya Haddad; Ruba Abu Ahmad; Sami Abu El Hija; Rand Abboud; Mahmud Mahamid; Rinaldo Pellicano; Amir Mari Journal: J Clin Med Date: 2020-09-14 Impact factor: 4.241